An abundance of evidence shows supporting roles for tetraspanin proteins in human cancer.
Many studies show that the expression of tetraspanins correlates with tumour stage, tumour …

Transmembrane proteins of the tetraspanin superfamily are implicated in a broad spectrum
of cellular processes in many biological systems in both health and disease. Tetraspanins …

Tetraspanins, also called tetraspans or the transmembrane 4 superfamily (TM4SF), are cell-
surface proteins that span the membrane four times and are found on many different cell …

Transmembrane protein tetraspanins either promote or suppress tumor invasion and
metastasis. Their effects on tumor progression depend on the multimolecular …

Human tetraspanin proteins are a group of 33 highly hydrophobic membrane proteins that
can form complexes in cholesterol‐rich microdomains, distinct from lipid rafts, on the cell …

Tetraspanins are integral membrane proteins involved in a variety of physiological and
pathological processes. In cancer, clinical and experimental studies have reported a link …

Tumours progress through a cascade of events that enable the formation of metastases.
Some of the components that are required for this fatal process are well established …

Cell-surface proteins of the tetraspanin family are small, and often hidden by a canopy of tall
glycoprotein neighbours in the cell membrane. Consequently, tetraspanins have been …

The tetraspanin transmembrane proteins have emerged as key players in malignancy, the
immune system, during fertilization and infectious disease processes. Tetraspanins engage …

Tetraspanins are a family of proteins with four transmembrane domains that play a role in
many aspects of cell biology and physiology; they are also used by several pathogens for …