Gene targeting studies in primary human islets could advance our understanding of
mechanisms driving diabetes pathogenesis. Here, we demonstrate successful genome …

Understanding the molecular mechanisms behind beta cell dysfunction is essential for the
development of effective and specific approaches for diabetes care and prevention …

The inheritance of variants that lead to coding changes in, or the mis-expression of, genes
critical to pancreatic beta cell function can lead to alterations in insulin secretion and …

Abstract Type 2 diabetes (T2D) is a global pandemic with a strong genetic component, but
most causal genes influencing the disease risk remain unknown. It is clear, however, that the …

Diabetes mellitus is a metabolic disease, characterized by chronic hyperglycemia caused by
an abnormality in insulin secretion or action. Millions of people across the world are affected …

Diabetes mellitus (DM) is a common metabolic disorder caused mainly by combining two
primary factors, which are (1) defects in insulin production by the pancreatic β-cells and (2) …

CRISPR/Cas9 has revolutionized the genome-editing field. So far, successful application in
human adipose tissue has not been convincingly shown. We present a method for gene …

Objective α-cells are the second most prominent cell type in pancreatic islets and are
responsible for producing glucagon to increase plasma glucose levels in times of fasting. α …

Abstract CRISPR (Clustered Regularly Interspaced Short Palindromic Repeats) technology
has emerged as a powerful technology for genome editing and is now widely used in basic …

Identification of the genes and processes mediating genetic association signals for complex
diseases represents a major challenge. As many of the genetic signals for type 2 diabetes …