Das Marfan-Syndrom (MFS) ist eine relativ häufige autosomal dominant vererbte Störung
des Bindegewebes mit zahlreichen Symptomen im Skelettsystem, am Auge, und im …

Thoracic aortic aneurysm (TAA) is the life-threatening complication of Marfan syndrome
(MFS), a connective tissue disorder caused by mutations in the fibrillin-1 gene. TAA is …

Marfan syndrome (MFS) is an autosomal dominant genetic disorder caused by mutations in
the fibrillin-1 gene. Acute aortic dissection is the leading cause of death in patients suffering …

Marfan syndrome (MFS) is a connective tissue disorder with multiple organ manifestations.
The genetic cause of this syndrome is the mutation of the FBN1 gene, encoding the …

Dissecting aortic aneurysm is the hallmark of Marfan syndrome (MFS) and the result of
mutations in fibrillin-1, the major constituent of elastin-associated extracellular microfibrils. It …

Marfan syndrome (MFS) is an inherited autosomal dominant multisystem disease caused by
mutations in the FBN1 gene encoding fibrillin-1, an extracellular matrix glycoprotein widely …

Marfan syndrome is a systemic connective tissue disorder that is inherited in an autosomal-
dominant pattern with variable penetrance. Although there are many clinical manifestations …

OBJECTIVE: Fibrillin-1 hypomorphic mice (mgR/mgR) are accepted as a model of Marfan
syndrome. Phenotypic investigations of this mouse have not previously included …

Background: Marfan syndrome (MFS), an inherited disorder of connective tissue
characterized by abnormalities in the skeletal, ocular, and cardiovascular systems, is caused …

Marfan syndrome (MFS) is an autosomal dominant connective tissue disorder caused by
fibrillin 1 (FBN1) gene mutations that results in defects in the skeletal, ocular, and …