Common driver mutations and programmed death-ligand 1 expression in advanced non-small cell lung cancer in smokers and never smokers

CK Liam, CY Yew, YK Pang, CK Wong, ME Poh… - BMC cancer, 2023 - Springer
Background In non-small cell lung cancer (NSCLC), there may be a relationship between
programmed death-ligand 1 (PD-L1) expression, driver mutations and cigarette smoking …

PD-L1 expression according to the EGFR status in primary lung adenocarcinoma

K Takada, G Toyokawa, T Tagawa, K Kohashi… - Lung Cancer, 2018 - Elsevier
Objectives It was reported that programmed cell death-ligand 1 (PD-L1) expression is
associated with smoking and wild-type epidermal growth factor receptor (EGFR) in lung …

Comprehensive analysis of PD‐L1 in non‐small cell lung cancer with emphasis on survival benefit, impact of driver mutation and histological types, and archival tissue

CC Wang, KT Huang, HC Chang, CC Tseng… - Thoracic …, 2022 - Wiley Online Library
Background The aim of the study was to assess programmed death‐ligand‐1 (PD‐L1)
expression in different histological types and gene mutation status of patients with non‐small …

Various impacts of driver mutations on the PD-L1 expression of NSCLC

CH Chu, YH Huang, PH Lee, KH Hsu, KC Chen, KY Su… - Plos one, 2022 - journals.plos.org
We aimed to evaluate whether different driver mutations have varying impacts on the
programmed cell death-ligand 1 (PD-L1) expression of non-small cell lung cancer (NSCLC) …

Association of PD‐L1 expression with driver gene mutations and clinicopathological characteristics in non‐small cell lung cancer: A real‐world study of 10 441 …

G Ruiz, D Enrico, YD Mahmoud, A Ruiz… - Thoracic …, 2024 - Wiley Online Library
Background Programmed death ligand‐1 (PD‐L1) expression is a well‐known predictive
biomarker of response to immune checkpoint blockade in non‐small cell lung cancer …

Predictive value of oncogenic driver subtype, programmed death‐1 ligand (PD‐L1) score, and smoking status on the efficacy of PD‐1/PD‐L1 inhibitors in patients with …

TL Ng, Y Liu, A Dimou, T Patil, DL Aisner, Z Dong… - Cancer, 2019 - Wiley Online Library
Background This multicenter, retrospective study explored the value of oncogene driver
subtype, programmed death‐1 ligand (PD‐L1) status, and smoking status for predicting …

Clinicopathological and molecular characteristics associated with PD-L1 expression in non-small cell lung cancer: a large-scale, multi-center, real-world study in …

Q Zheng, Y Huang, X Zeng, X Chen, S Shao… - Journal of Cancer …, 2021 - Springer
Purpose The study aimed to evaluate the clinicopathological and molecular profiles
associated with programmed death ligand 1 (PD-L1) expression in non-small cell lung cell …

[HTML][HTML] Clinical significance of PD-L1 protein expression in surgically resected primary lung adenocarcinoma

K Takada, T Okamoto, F Shoji, M Shimokawa… - Journal of Thoracic …, 2016 - Elsevier
Introduction The clinicopathological features of carcinomas expressing programmed death
ligand 1 (PD-L1) and their associations with common driver mutations, such as mutations in …

[HTML][HTML] Chronic nicotine exposure affects programmed death-ligand 1 expression and sensitivity to epidermal growth factor receptor-tyrosine kinase inhibitor in lung …

CD Yeo, IK Kim, WH Ban, HS Kang… - Translational Cancer …, 2019 - ncbi.nlm.nih.gov
Background Smoking histories are independently associated with poor response to
epidermal growth factor receptor (EGFR)-tyrosine kinase inhibitors (TKIs) in non-small cell …

Programmed death-ligand 1 expression and its associations with clinicopathological features, prognosis, and driver oncogene alterations in surgically resected lung …

K Takamochi, K Hara, T Hayashi, S Kohsaka… - Lung Cancer, 2021 - Elsevier
Objectives Programmed death-ligand 1 (PD-L1) expression is a predictive biomarker of
response to immunotherapies targeting programmed death-1/PD-L1 in advanced-stage lung …