Cyclin dependent kinases (CDKs) are serine/threonine kinases that are proposed as
promising candidate targets for cancer treatment. These proteins complexed with cyclins …

Cyclin dependent kinases are proline-directed serine/threonine protein kinases that are
traditionally activated upon association with a regulatory subunit. For most CDKs, activation …

Cyclin-dependent kinases (CDKs) are proteins pivotal to a wide range of cellular functions,
most importantly cell division and transcription, and their dysregulations have been …

Cdk5 is an atypical cyclin-dependent kinase that is well characterized for its role in the
central nervous system rather than in the cell cycle. However, Cdk5 has been recently …

Highlights•CDK2 has key roles in cell cycle, DNA replication and DNA damage.•Multiple
biomarkers can indicate increased CDK2 activity.•Some cancers have particular …

Abstract Cyclin-dependent kinase 12 (CDK12) is a member of the CDK family of proteins
(CDK) and is critical for cancer development. Years of study into CDK12 have generated …

Cyclin-dependent kinase (CDK) inhibitors have been developed as potential anticancer
therapeutics and several nonselective compounds are currently in advanced clinical trials …

Cyclin-dependent kinase 6 (CDK6) plays a vital role in regulating the progression of the cell
cycle. More recently, CDK6 has also been shown to have a transcriptional role in tumor …

Cyclin-dependent kinase 2 (CDK2) drives the progression of cells into the S-and M-phases
of the cell cycle. CDK2 activity is largely dispensable for normal development, but it is …

Cyclin-dependent kinase 8 (CDK8) plays a vital role in regulating transcription either
through its association with the Mediator complex or by phosphorylating transcription factors …