There is no effective therapy for the lately increased incidence of glioblastoma multiforme
(GBM)—the most common primary brain tumor characterized by a high degree of …

Glioblastoma is a highly aggressive and lethal brain tumor, with limited treatment options.
Abnormal activation of the neddylation pathway is observed in glioblastoma, and the …

Neddylation is a post-translational protein modification process associated with
carcinogenesis and cancer development. MLN4924, a pharmaceutical neddylation inhibitor …

Background: Neddylation is an important post-translational modification of proteins, in which
a NEDD8 (neural-precursor-cell-expressed developmentally down-regulated 8) is covalently …

Background The neddylation pathway has been recently identified as an attractive
anticancer target, and MLN4924, a specific NEDD8-activating enzyme inhibitor, has been …

Many conventional chemotherapeutic drugs exert their cytotoxic function by inducing DNA
damage in the tumor cell. Therefore, a cell-inherent DNA repair pathway, which reverses the …

Protein neddylation, a newly characterized posttranslational modification that adds the
ubiquitin-like molecule NEDD8 to substrates, modulates important biological processes …

Inhibiting the protein neddylation pathway using the NEDD8‑activating enzyme inhibitor
MLN4924 represents an attractive anticancer strategy having been demonstrated to exhibit …

Malignant glioma is the most common primary brain tumor. Malignant melanoma is the most
malignant of skin tumor. The two malignancies are poorly responsive to conventional …

Neddylation, a post-translational modification that conjugates an ubiquitin-like protein
NEDD8 to substrate proteins, is an important biochemical process that regulates protein …