Circulating Neurofilament Light Chain Levels Increase with Age and Are Associated with Worse Physical Function and Body Composition in Men but Not in Women

X Capo, AM Galmes-Panades… - International journal of …, 2023 - mdpi.com
This study aimed to assess the relationship between age-related changes in Neurofilament
Light Chain (NFL), a marker of neuronal function, and various factors including muscle …

Plasma neurofilament light levels associate with muscle mass and strength in middle‐aged and older adults: Findings from GenoFit

J Pratt, G De Vito, R Segurado… - Journal of Cachexia …, 2022 - Wiley Online Library
Background Efforts to enhance diagnostic measures for sarcopenia have led to an
increased focus on the screening utility of blood‐based biomarkers. In this regard …

[HTML][HTML] Factors influencing serum neurofilament light chain levels in normal aging

M Koini, L Pirpamer, E Hofer, A Buchmann… - Aging (Albany …, 2021 - ncbi.nlm.nih.gov
Objective: Serum neurofilament light (sNfL) is a promising marker for neuro-axonal damage
and it is now well known that its levels also increase with higher age. However, the effect of …

Renal function is associated with blood neurofilament light chain level in older adults

S Akamine, N Marutani, D Kanayama, S Gotoh… - Scientific reports, 2020 - nature.com
Neurofilament light chain (NfL) is a novel biomarker of neurodegenerative diseases. It is
detectable in the peripheral blood, allowing low-invasive assessment of early signs of …

Association of plasma neurofilament light chain with glycaemic control and insulin resistance in middle-aged adults

RN Thota, P Chatterjee, S Pedrini, E Hone… - Frontiers in …, 2022 - frontiersin.org
Aims This study aimed to determine the association of plasma neurofilament light (NfL), a
marker of neurodegeneration, with diabetes status and glycaemic parameters in people with …

Elevated Serum neurofilament light chain levels are associated with all-cause mortality: evidence from national health and nutrition examination survey

X Chen, Y Lin, K Wei - The Journals of Gerontology: Series A, 2023 - academic.oup.com
Background Several studies have reported the association between blood neurofilament
light chain (NfL) levels and all-cause mortality. However, the generalizability of these …

Serum neurofilament light chain as a prognostic marker of all-cause mortality in a national sample of US adults

MA Beydoun, N Noren Hooten, MF Georgescu… - European Journal of …, 2024 - Springer
Neurofilament light chain (NfL) is a neuron-specific structural protein released into the
extracellular space, including body fluids, upon neuroaxonal damage. Despite evidence of a …

Serum neurofilament light levels are predictive of all-cause mortality in late middle-aged individuals

AD Nguyen, TK Malmstrom, G Aggarwal, DK Miller… - …, 2022 - thelancet.com
Background Blood biomarkers can offer valuable and easily accessible indicators of normal
biological processes, pathogenic conditions, and responses to therapeutic interventions …

A neuronal blood marker is associated with mortality in old age

SA Kaeser, B Lehallier, M Thinggaard, LM Häsler… - Nature Aging, 2021 - nature.com
Neurofilament light chain (NfL) has emerged as a promising blood biomarker for the
progression of various neurological diseases. NfL is a structural protein of nerve cells, and …

[HTML][HTML] BMI and allostatic load are directly associated with longitudinal increase in plasma neurofilament light among urban middle-aged adults

MA Beydoun, NN Hooten, AI Maldonado… - The Journal of …, 2022 - Elsevier
Background Plasma neurofilament light chain (NfL) is a novel biomarker for age-related
neurodegenerative disease. We tested whether NfL may be linked to cardiometabolic risk …