Complex 3D bioengineered tumour models provide the opportunity to better capture the
heterogeneity of patient tumours. Patient-derived organoids are emerging as a useful tool to …

Patient‐derived organoids have emerged as a useful tool to model tumour heterogeneity.
Scaling these complex culture models while enabling stratified analysis of different cellular …

Organotypic models of patient-specific tumours are revolutionizing our understanding of
cancer heterogeneity and its implications for personalized medicine. These advancements …

Human organoids have the potential to revolutionize in vitro disease modeling by providing
multicellular architecture and function that are similar to those in vivo. This innovative and …

Organoids are in vitro self-assembling, organ-like, three-dimensional cellular structures that
stably retain key characteristics of the respective organs. Organoids can be generated from …

Patient‐derived organoids (PDOs) developed ex vivo and in vitro are increasingly used for
therapeutic screening. They provide a more physiologically relevant model for drug …

The recent advances in in vitro 3D culture technologies, such as organoids, have opened
new avenues for the development of novel, more physiological human cancer models. Such …

Adult stem cell–based organoid technology is a versatile tool for the generation and long-
term maintenance of near-native 3D epithelial tissues in vitro. The generation of cancer …

Organoid cultures are widely used for tumor modeling because they preserve many
phenotypic features of cancer cells in vivo. However, current organoids present issues of …

Over the past decade, advances in biomedical and tissue engineering technologies, such as
cell culture techniques, biomaterials, and biofabrication, have driven increasingly …