Application of 3D hepatic plate-like liver model for statin-induced hepatotoxicity evaluation
J Xu, D Pan, W Liao, Z Jia, M Pan, J Weng… - … in Bioengineering and …, 2022 - frontiersin.org
Background: Drug-induced liver injury is one of the main reasons of withdrawals of drugs in
postmarketing stages. However, an experimental model (s) which can accurately …
postmarketing stages. However, an experimental model (s) which can accurately …
Paper supported long-term 3D liver co-culture model for the assessment of hepatotoxic drugs
Preservation of hepatic phenotype and functions in vitro has always been a great challenge
for the reconstruction of liver tissue engineering and in pharmaceutical research studies …
for the reconstruction of liver tissue engineering and in pharmaceutical research studies …
An integrated biomimetic array chip for establishment of collagen‐based 3D primary human hepatocyte model for prediction of clinical drug‐induced liver injury
RR Xiao, T Lv, X Tu, P Li, T Wang… - Biotechnology and …, 2021 - Wiley Online Library
Drug‐induced liver injury (DILI) is a leading cause of therapy failure in the clinic and also
contributes much to acute liver failure cases. Investigations of predictive sensitivity in animal …
contributes much to acute liver failure cases. Investigations of predictive sensitivity in animal …
Advantages of in vitro 3D liver model in study of liver toxicity
X LU, H ZHAO, X WANG, Z HUANG… - Acta Pharmaceutica …, 2017 - pesquisa.bvsalud.org
This study was conducted to establish an in vitro 3D liver model and apply it to the drug liver
toxicity evaluation. The 3D multicellular sphere model of HepaRG cells was established by …
toxicity evaluation. The 3D multicellular sphere model of HepaRG cells was established by …
A novel evaluation method for determining drug-induced hepatotoxicity using 3D bio-printed human liver tissue
I Ide, E Nagao, S Kajiyama… - … Mechanisms and Methods, 2020 - Taylor & Francis
Predicting drug-induced liver injury is important in early stage drug discovery; however, an
accurate prediction with existing hepatotoxicity evaluation tools is difficult. Conventional …
accurate prediction with existing hepatotoxicity evaluation tools is difficult. Conventional …
Three-dimensional cell Co-culture liver models and their applications in pharmaceutical research
Y Ma, L Hu, J Tang, W Guo, Y Feng, Y Liu… - International Journal of …, 2023 - mdpi.com
As the primary site for the biotransformation of drugs, the liver is the most focused on organ
type in pharmaceutical research. However, despite being widely used in pharmaceutical …
type in pharmaceutical research. However, despite being widely used in pharmaceutical …
Evaluation of 3D re-cellularized tissue engineering: a drug-induced hepatotoxicity model for hepatoprotectant research
W Han, M Ding, S Liu, Y Chen… - … Mechanisms and Methods, 2019 - Taylor & Francis
Background: Application of hepatoprotectants, such as drugs or cytokines, can reduce drug-
induced hepatotoxicity (DIH). Due to species-specific differences and abnormal cell polarity …
induced hepatotoxicity (DIH). Due to species-specific differences and abnormal cell polarity …
A 3D cell printing-fabricated HepG2 liver spheroid model for high-content in situ quantification of drug-induced liver toxicity
S Hong, JM Song - Biomaterials science, 2021 - pubs.rsc.org
3D spheroid cultures are attractive candidates for application in in vitro drug-induced
hepatotoxicity testing models to improve the reliability of biological information obtainable …
hepatotoxicity testing models to improve the reliability of biological information obtainable …
Porcine hepatocytes culture on biofunctionalized 3D inverted colloidal crystal scaffolds as an in vitro model for predicting drug hepatotoxicity
As drug-induced hepatotoxicity represents one of the most common causes of drug failure,
three-dimensional (3D) in vitro liver platforms represent a fantastic toolbox to predict drug …
three-dimensional (3D) in vitro liver platforms represent a fantastic toolbox to predict drug …
3D human nonalcoholic hepatic steatosis and fibrosis models
This study presents a simple and robust three-dimensional human hepatic tissue model to
emulate steatotic and fibrotic conditions and provide an in vitro model for drug testing and …
emulate steatotic and fibrotic conditions and provide an in vitro model for drug testing and …