Background: Drug-induced liver injury is one of the main reasons of withdrawals of drugs in
postmarketing stages. However, an experimental model (s) which can accurately …

Preservation of hepatic phenotype and functions in vitro has always been a great challenge
for the reconstruction of liver tissue engineering and in pharmaceutical research studies …

Drug‐induced liver injury (DILI) is a leading cause of therapy failure in the clinic and also
contributes much to acute liver failure cases. Investigations of predictive sensitivity in animal …

This study was conducted to establish an in vitro 3D liver model and apply it to the drug liver
toxicity evaluation. The 3D multicellular sphere model of HepaRG cells was established by …

Predicting drug-induced liver injury is important in early stage drug discovery; however, an
accurate prediction with existing hepatotoxicity evaluation tools is difficult. Conventional …

As the primary site for the biotransformation of drugs, the liver is the most focused on organ
type in pharmaceutical research. However, despite being widely used in pharmaceutical …

Background: Application of hepatoprotectants, such as drugs or cytokines, can reduce drug-
induced hepatotoxicity (DIH). Due to species-specific differences and abnormal cell polarity …

3D spheroid cultures are attractive candidates for application in in vitro drug-induced
hepatotoxicity testing models to improve the reliability of biological information obtainable …

As drug-induced hepatotoxicity represents one of the most common causes of drug failure,
three-dimensional (3D) in vitro liver platforms represent a fantastic toolbox to predict drug …

This study presents a simple and robust three-dimensional human hepatic tissue model to
emulate steatotic and fibrotic conditions and provide an in vitro model for drug testing and …