Comprehensive phenotyping in multiple sclerosis: discovery based proteomics and the current understanding of putative biomarkers

KC O'Connor, SM Roy, CH Becker, DA Hafler… - Disease …, 2006 - content.iospress.com
Currently, there is no single test for multiple sclerosis (MS). Diagnosis is confirmed through
clinical evaluation, abnormalities revealed by magnetic resonance imaging (MRI), and …

Serum proteomics in multiple sclerosis disease progression

H Tremlett, DLY Dai, Z Hollander, A Kapanen, T Aziz… - Journal of …, 2015 - Elsevier
Multiple sclerosis (MS) is associated with chronic degeneration of the central nervous
system and may cause permanent neurological problems and considerable disability. While …

Proteomics technologies for biomarker discovery in multiple sclerosis

V Singh, RQ Hintzen, TM Luider, MP Stoop - Journal of neuroimmunology, 2012 - Elsevier
Multiple sclerosis is a disabling inflammatory and neurodegenerative disorder that
predominantly affects young adults. There is a great need for biomarkers, which could …

New technologies for biomarker discovery in multiple sclerosis

M Comabella, MK Racke - Journal of neuroimmunology, 2012 - jni-journal.com
Multiple sclerosis (MS) is a complex and heterogeneous disease in many different aspects,
for example, in its clinical manifestations, disease course, neuroradiological findings …

Cerebrospinal fluid proteomics in multiple sclerosis

AC Kroksveen, JA Opsahl, A Guldbrandsen… - … et Biophysica Acta (BBA …, 2015 - Elsevier
Multiple sclerosis (MS) is an immune mediated chronic inflammatory disease of the central
nervous system usually initiated during young adulthood, affecting approximately 2.5 million …

Ten years of proteomics in multiple sclerosis

AS Farias, F Pradella, A Schmitt, LMB Santos… - …, 2014 - Wiley Online Library
Multiple sclerosis, which is the most common cause of chronic neurological disability in
young adults, is an inflammatory, demyelinating, and neurodegenerative disease of the …

CSF proteome in multiple sclerosis subtypes related to brain lesion transcriptomes

ML Elkjaer, A Nawrocki, T Kacprowski, P Lassen… - Scientific reports, 2021 - nature.com
To identify markers in the CSF of multiple sclerosis (MS) subtypes, we used a two-step
proteomic approach:(i) Discovery proteomics compared 169 pooled CSF from MS subtypes …

Application of quantitative proteomics technologies to the biomarker discovery pipeline for multiple sclerosis

LF Dagley, A Emili, AW Purcell - Proteomics–Clinical …, 2013 - Wiley Online Library
Multiple sclerosis is an inflammatory‐mediated demyelinating disorder most prevalent in
young C aucasian adults. The various clinical manifestations of the disease present several …

Posttranslational modifications of proteins are key features in the identification of CSF biomarkers of multiple sclerosis

IL Salazar, AST Lourenço, B Manadas… - Journal of …, 2022 - Springer
Background Multiple sclerosis is an inflammatory and degenerative disease of the central
nervous system (CNS) characterized by demyelination and concomitant axonal loss. The …

Genomic, proteomic, and systems biology approaches in biomarker discovery for multiple sclerosis

CC Huizar, I Raphael, TG Forsthuber - Cellular immunology, 2020 - Elsevier
Multiple sclerosis (MS) is a neuroinflammatory disorder characterized by autoimmune-
mediated inflammatory lesions in CNS leading to myelin damage and axonal loss. MS is a …