Idiopathic pulmonary fibrosis (IPF) is a progressive and fatal degenerative lung disease of
unknown etiology. Although in its final stages it implicates, in a reactive manner, all lung cell …

Idiopathic pulmonary fibrosis (IPF) is a form of usual interstitial pneumonia (UIP), though its
origin is unknown. IPF remains one of the most aggressive and lethal forms of interstitial …

Persistence of transitional epithelial cell states during lung repair are implicated in the
pathobiology of idiopathic pulmonary fibrosis (IPF). However, it is unknown whether they …

Aberrant expansion of KRT5+ basal cells in the distal lung accompanies progressive
alveolar epithelial cell loss and tissue remodelling during fibrogenesis in idiopathic …

Epithelial cell dysfunction has emerged as a central component of the pathophysiology of
diffuse parenchymal diseases including idiopathic pulmonary fibrosis (IPF). Alveolar type 2 …

Single-cell transcriptomics analyses of the fibrotic lung uncovered two cell states critical to
lung injury recovery in the alveolar epithelium—a reparative transitional cell state in the …

Background Idiopathic pulmonary fibrosis (IPF) is an incurable disease characterized by
progressive lung fibrosis ultimately resulting in respiratory failure and death. Recurrent micro …

We provide a single-cell atlas of idiopathic pulmonary fibrosis (IPF), a fatal interstitial lung
disease, by profiling 312,928 cells from 32 IPF, 28 smoker and nonsmoker controls, and 18 …

In idiopathic pulmonary fibrosis (IPF) constant epithelial micro-injury and aberrant
interactions within the stromal micro-environment lead to abnormal alveolar repair and …

A defining pathological feature of human lung fibrosis is localized tissue heterogeneity,
which challenges the interpretation of transcriptomic studies that typically lose spatial …