Medicinal chemistry of quinazolines as anticancer agents targeting tyrosine kinases

MF Zayed - Scientia Pharmaceutica, 2023 - mdpi.com
Cancer is a large group of diseases that can affect any organ or body tissue due to the
abnormal cellular growth with the unknown reasons. Many of the existing chemotherapeutic …

Therapeutic progression of quinazolines as targeted chemotherapeutic agents

R Bansal, A Malhotra - European Journal of Medicinal Chemistry, 2021 - Elsevier
Presently cancer is a grave health issue with predominance beyond restrictions. It can affect
any organ of the body. Most of the available chemotherapeutic drugs are highly toxic, not …

Bestowal of quinazoline scaffold in anticancer drug discovery

R Das, DK Mehta, M Dhanawat - Anti-Cancer Agents in …, 2021 - ingentaconnect.com
Background: Cancer is one of the major causes of human mortality worldwide. A number of
existing antineoplastic medications and treatment regimens are already working in the field …

An insight into the therapeutic potential of quinazoline derivatives as anticancer agents

I Ahmad - MedChemComm, 2017 - pubs.rsc.org
Cancer is one of the major causes of worldwide human mortality. A wide range of cytotoxic
drugs are available on the market, and several compounds are in different phases of clinical …

Quinazoline derivatives as potential anticancer agents: a patent review (2007–2010)

G Marzaro, A Guiotto, A Chilin - Expert opinion on therapeutic …, 2012 - Taylor & Francis
Introduction: Due to the increase in knowledge about cancer pathways, there is a growing
interest in finding novel potential drugs. Quinazoline is one of the most widespread scaffolds …

Quinazoline derivatives as anticancer drugs: a patent review (2011–present)

S Ravez, O Castillo-Aguilera, P Depreux… - Expert opinion on …, 2015 - Taylor & Francis
Introduction: Quinazoline is one of the most studied moieties in medicinal chemistry due to
the wide range of biological properties such as the anticancer, antibacterial, anti …

Current perspectives on quinazolines with potent biological activities: A review

T Gupta, A Rohilla, A Pathak, MJ Akhtar… - Synthetic …, 2018 - Taylor & Francis
Quinazoline is a heterocyclic compound having biological activities. It is aromatic in nature
having bicyclic structure containing benzene ring and pyrimidine ring. Quinazoline and its …

[HTML][HTML] Synthesis, method optimization, anticancer activity of 2, 3, 7-trisubstituted quinazoline derivatives and targeting EGFR-tyrosine kinase by rational approach …

MN Noolvi, HM Patel - Arabian Journal of Chemistry, 2013 - Elsevier
A novel 3-(substituted benzylideneamino)-7-chloro-2-phenyl quinazoline-4 (3H)-one (7–27)
has been synthesized and characterised by IR, 1H NMR, 13C NMR spectroscopy, and …

[HTML][HTML] Recent advances in 4-aminoquinazoline based scaffold derivatives targeting EGFR kinases as anticancer agents

RSM Ismail, NSM Ismail, S Abuserii… - Future Journal of …, 2016 - Elsevier
Quinazoline derivatives are fused heterocyclic ring systems which have been explored for
their inhibitory activity towards various protein kinase enzymes and their role as anticancer …

Medicinal and biological significance of quinazoline: a highly important scaffold for drug discovery: a review.

A Vijaychand, SN Manjula, EN Bharath, B Divya - 2011 - cabidigitallibrary.org
This article outlines the medicinal and biological significance of one of the most important
heterocycles, the quinazoline. Quinazoline is a highly active scaffold exhibiting wide variety …