Energy balance involves the adjustment of food intake, energy expenditure and body fat
reserves through homeostatic pathways. These pathways include a multitude of biochemical …

Abstract Purpose of Review Environmental toxicants are increasingly implicated in the
global decline in metabolic health. Focusing on diabetes, herein, the molecular and cellular …

Endocrine disrupting chemicals (EDCs), a heterogeneous group of exogenous chemicals
that can interfere with any aspect of endogenous hormones, represent an emerging global …

Obesity and associated metabolic disorders represent a major societal challenge in health
and quality of life with large psychological consequences in addition to physical disabilities …

The recent dramatic rise in obesity rates is an alarming global health trend that consumes an
ever increasing portion of health care budgets in Western countries. The root cause of …

Health problems resulting from obesity could offset many of the recent health gains achieved
by modern medicine, and obesity may replace tobacco as the number one health risk for …

Metabolic disease rates have increased dramatically over the last four decades. Classic
understanding of metabolic physiology has attributed these global trends to decreased …

Endocrine disrupting chemicals (EDCs) are compounds that are part of everyday consumer
products and industrial manufacturing processes. EDCs can interfere with the endocrine …

Excessive energy intake and reduced energy expenditure drive the development of insulin
resistance and metabolic diseases such as obesity and type 2 diabetes mellitus. Metabolic …

Feeding behavior is critical for survival. In addition to providing all of the body's
macronutrients (carbohydrates, lipids, and proteins) and most micronutrients (minerals and …