Lobular neoplasia (LN) is a term that encompasses both lobular carcinoma in situ and
atypical lobular hyperplasia. These lesions have been shown to constitute both risk …

Invasive lobular carcinoma (ILC) and lobular carcinoma in situ characteristically show loss of
E-cadherin expression and so immunohistochemistry for E-cadherin is being increasingly …

The distinction between lobular neoplasia and infiltrating lobular carcinoma from ductal
neoplasia and infiltrating duct carcinoma with equivocal histologic features may present a …

Tumor development from an early lesion through to invasive disease is not a clearly defined
progression in the breast. Studies of invasive lobular carcinoma have reported mutations …

Pleomorphic lobular carcinoma of the breast is a variant of infiltrating lobular carcinoma that
has poor prognosis. The pleomorphic appearance of this variant hinders its correct …

Lobular neoplasia has been traditionally recognized as a marker of increased risk for
subsequent breast carcinoma development; however, molecular studies suggest that it also …

Immunohistochemical analysis of E‐cadherin has changed the way lobular neoplasia is
perceived. It has helped to classify difficult cases of carcinoma in situ with indeterminate …

Background Although virtually all cases of lobular carcinoma in situ lack E-cadherin
expression, a proportion of morphologically typical invasive lobular carcinomas (ILCs) retain …

Invasive lobular carcinoma (ILC) represents the second most common subtype of breast
cancer (BC), accounting for up to 15% of all invasive BC. Loss of cell adhesion due to …

Invasive lobular carcinoma (ILC) and lobular neoplasia (LN) are two distinct conditions that
still pose challenges regarding to their classification, diagnosis and management. Although …