Selective inhibition of protein kinase C isozymes by the indolocarbazole Gö 6976
G Martiny-Baron, MG Kazanietz, H Mischak… - Journal of Biological …, 1993 - Elsevier
Indolocarbazoles have been identified as novel inhibitors of protein kinase C (PKC), with Gö
6976 as one of its most potent and selective representatives. Recombinant PKC isozymes …
6976 as one of its most potent and selective representatives. Recombinant PKC isozymes …
Isoenzyme specificity of bisindolylmaleimides, selective inhibitors of protein kinase C
SE Wilkinson, PJ Parker, JS Nixon - Biochemical Journal, 1993 - portlandpress.com
The protein kinase C (PKC) family of isoenzymes is believed to mediate a wide range of
signal-transduction pathways in many different cell types. A series of bisindolylmaleimides …
signal-transduction pathways in many different cell types. A series of bisindolylmaleimides …
Inhibition of protein kinase C μ by various inhibitors. Inhibition from protein kinase c isoenzymes
M Gschwendt, S Dieterich, J Rennecke, W Kittstein… - FEBS letters, 1996 - Elsevier
Various inhibitors were tested for their potential to suppress the kinase activity of protein
kinase C μ (PKCμ) in vitro and in vivo. Among the staurosporine-derived, rather selective …
kinase C μ (PKCμ) in vitro and in vivo. Among the staurosporine-derived, rather selective …
(S)-13-[(Dimethylamino)methyl]-10,11,14,15-tetrahydro-4,9:16,21-dimetheno- 1H,13H-dibenzo[e,k]pyrrolo[3,4-h][1,4,13]oxadiazacyclohexadecene-1,3(2H) …
MR Jirousek, JR Gillig, CM Gonzalez… - Journal of medicinal …, 1996 - ACS Publications
Protein kinase C (PKC) is a family of closely related serine and threonine kinases.
Overactivation of some PKC isozymes has been postulated to occur in several disease …
Overactivation of some PKC isozymes has been postulated to occur in several disease …
Therapeutic potential of protein kinase C inhibitors
D Bradshaw, CH Hill, JS Nixon, SE Wilkinson - Agents and Actions, 1993 - Springer
The serine/threonine protein kinase, protein kinase C (PKC) is a family of closely related
isoforms which are physiologically activated by diacylglycerol generated by the binding of a …
isoforms which are physiologically activated by diacylglycerol generated by the binding of a …
[HTML][HTML] Indolocarbazoles as anti-cancer agents
M Prudhomme - Current Pharmaceutical Design, 1997 - books.google.com
Protein kinase C (PKC) is a family of phospholipid-dependent serinelthreonine protein
kinases that plays a key role in signal transduction. Consequently, PKC controls a large …
kinases that plays a key role in signal transduction. Consequently, PKC controls a large …
The bisindolylmaleimide GF 109203X is a potent and selective inhibitor of protein kinase C
D Toullec, P Pianetti, H Coste, P Bellevergue… - Journal of Biological …, 1991 - Elsevier
Staurosporine is the most potent inhibitor of protein kinase C (PKC) described in the
literature with a half-maximal inhibitory concentration (IC50) of 10 nM. Nevertheless, this …
literature with a half-maximal inhibitory concentration (IC50) of 10 nM. Nevertheless, this …
The potential for isoenzyme‐selective modulation of protein kinase C
J Hofmann - The FASEB Journal, 1997 - Wiley Online Library
Protein kinase C (PKC) is a phospholipid‐dependent serine/threonine kinase family
consisting of at least 11 closely related isoenzymes. The different PKC isoenzymes play …
consisting of at least 11 closely related isoenzymes. The different PKC isoenzymes play …
Differential inhibition of protein kinase C isozymes by UCN-01, a staurosporine analogue.
CM Seynaeve, MG Kazanietz, PM Blumberg… - Molecular …, 1994 - ASPET
UCN-01 (7-hydroxystaurosporine) has been demonstrated to be a potent inhibitor of tumor
cell growth both in cell culture and with in vivo xenograft models. The ability of UCN-01 to …
cell growth both in cell culture and with in vivo xenograft models. The ability of UCN-01 to …
Pharmacologic modulation of protein kinase C isozymes: the role of RACKs and subcellular localisation
M CSUKAI, D MOCHLY-ROSEN - Pharmacological research, 1999 - Elsevier
Protein kinase C (PKC) isozymes are highly homologous kinases and several different
isozymes can be present in a cell. Each isozyme is likely to mediate unique functions, but …
isozymes can be present in a cell. Each isozyme is likely to mediate unique functions, but …