Cystic fibrosis (CF) is the most common autosomal recessive disease in Caucasians with a
reported incidence of 1 in every 3200 live births. Most strikingly, CF is associated with early …

Background A mathematical model describing mucociliary clearance in cystic fibrosis (CF)
patients and its development with progressing course of the disease was developed. The …

In cystic fibrosis, statistical models have been more successful in predicting mortality than
the time course of clinical status. We develop a system of partial differential equations that …

Cystic fibrosis (CF) is characterized by increased ventilation inhomogeneity (VI). The
multiple breath washout (MBW) is a lung function test that measures the degree of VI …

Dehydration of mucus in the lungs of cystic fibrosis (CF) patients can inhibit mucociliary
clearance (MCC), resulting in mucus build-up and blockages. Prior mathematical models …

This chapter considers the investigation of airway clearance efficiency and dysfunction using
rheological measurements, modeling and simulations of mucus flows. The work is mainly …

RATIONALE: Cystic Fibrosis (CF) is an inherited disease associated with a severely
impaired mucociliary clearance that leads to chronic polymicrobial airway infection …

Mucociliary clearance and cough are the two main natural mucus draining methods in the
bronchial tree. If they are affected by a pathology, they can become insufficient or even …

Modelling the relationship between pulmonary function and survival in cystic fibrosis (CF) is
complicated by the fact that measures of pulmonary function commonly used such as the …

Mucociliary clearance (MC) protects the lung from pollutants by removing mucus from the
lung. Pathologies can affect MC and alter its efficiency. Changes in mucus physical …