RESUMO A amiodarona é um dos fármacos mais usados para o tratamento de arritmias
cardíacas, tanto ventriculares como supraventriculares. Apesar de sua eficácia, o uso da …

Background: The clinical usefulness of amiodarone for the treatment of cardiac arrhythmias
is limited by multiorgan toxicity, especially pulmonary and hepatic. There are conflicting …

Amiodarone is a potent anti-arrhythmic drug used for the treatment of cardiac arrhythmias.
Although, the effects of amiodarone are well characterized on post-ischemic heart and …

Although, the antiarrhythmic effect of amiodarone (AMD) is well characterized, the
mechanism of its toxicity on extracardiac tissues is still poorly understood. Several …

Background Amiodarone (AMD) and its metabolite N-desethylamiodarone can cause some
adverse effects, which include pulmonary toxicity. Some studies suggest that mitochondrial …

Free Radicals and Amiodarone Toxicity. Introduction: In vitro and in vivo studies were
performed to elucidate the pathogenesis of amiodarone toxicity. Methods and Results: Rats …

Amiodarone (AM) is an effective antidysrhythmic agent, restricted in use by the development
of adverse effects, including potentially fatal AM‐induced pulmonary toxicity (AIPT). Although …

Amiodarone (AM), a drug used in the treatment of cardiac dysrrhythmias, can produce
severe pulmonary adverse effects, including fibrosis. Although the pathogenesis of AM …

Amiodarone is one of the most effective anti-arrhythmic drugs available. However, its use is
often limited by potentially life-threatening toxicities, including hepatotoxicity and pulmonary …

Context: Amiodarone (an iodinated benzofuran) is a Class III antiarrhythmic drug that
produces significant pulmonary disease. Proposed mechanisms of this cytotoxicity include …