Four-week repeated exposure to tire-derived 6-PPD quinone causes multiple organ injury in male BALB/c mice

W He, A Gu, D Wang - Science of The Total Environment, 2023 - Elsevier
Abstract N-(1, 3-dimethylbutyl)-N′-phenyl-p-phenylenediamine quinone (6-PPDQ) is the
ozonation product of tire antioxidant 6-PPD. 6-PPDQ can be detected in different …

Long-term exposure to tire-derived 6-PPD quinone causes intestinal toxicity by affecting functional state of intestinal barrier in Caenorhabditis elegans

X Hua, X Feng, G Liang, J Chao, D Wang - Science of The Total …, 2023 - Elsevier
Abstract 2-((4-Methylpentan-2-yl) amino)-5-(phenylamino) cyclohexa-2, 5-diene-1, 4-dione
(6-PPDQ) is the ozonation product of 6-PPD, a commonly used tire preservative. Although …

Tire-rubber related pollutant 6-PPD quinone: A review of its transformation, environmental distribution, bioavailability, and toxicity

X Hua, D Wang - Journal of Hazardous Materials, 2023 - Elsevier
The antioxidant 6-PPD has been widely used to prevent cracking and thermal oxidative
degradation and to extend the service life of tire rubber. 6-PPD quinone (6-PPDQ) is formed …

Environmentally realistic dose of tire-derived metabolite 6PPD-Q exposure causes intestinal jejunum and ileum damage in mice via cannabinoid receptor-activated …

Y Yang, N Sun, J Lv, H Chen, H Wang, J Xu… - Science of The Total …, 2024 - Elsevier
Abstract N-(1, 3-dimethylbutyl)-N′-phenyl-p-phenylenediamine quinone (6PPD-Q) is a
quinone derivative of a common tire additive 6PPD, whose occurrence has been widely …

Environmental occurrence and toxicity of 6PPD quinone, an emerging tire rubber-derived chemical: a review

K Zoroufchi Benis, A Behnami, S Minaei… - … & Technology Letters, 2023 - ACS Publications
N-(1, 3-Dimethylbutyl)-N′-phenyl-p-phenylenediamine (6PPD) is a chemical added to tires
to prevent their oxidative degradation. 6PPD is highly reactive with ozone and oxygen …

Uptake and Biotransformation of the Tire Rubber-derived Contaminants 6-PPD and 6-PPD Quinone in the Zebrafish Embryo (Danio rerio)

N Grasse, B Seiwert, R Massei, S Scholz… - Environmental …, 2023 - ACS Publications
N-(1, 3-Dimethylbutyl)-N′-phenyl-p-phenylenediamine (6-PPD) is a widely used
antioxidant in tire rubber known to enter the aquatic environment via road runoff. The …

Oral exposure to tire rubber-derived contaminant 6PPD and 6PPD-quinone induce hepatotoxicity in mice

L Fang, C Fang, S Di, Y Yu, C Wang, X Wang… - Science of The Total …, 2023 - Elsevier
Abstract N-(1, 3-dimethylbutyl)-N′-phenyl-p-phenylenediamine (6PPD) is a widely used
additive for protecting various rubber products, and its product of oxidation N-(1, 3 …

Acute toxicity of a tire rubber-derived chemical, 6PPD quinone, to freshwater fish and crustacean species

K Hiki, K Asahina, K Kato, T Yamagishi… - … & Technology Letters, 2021 - ACS Publications
N-(1, 3-Dimethylbutyl)-N′-phenyl-p-phenylenediamine-quinone, also known as 6PPD
quinone, was recently identified as a toxic chemical that causes acute mortality in coho …

Exposure to the Tire Rubber-Derived Contaminant 6PPD-Quinone Causes Mitochondrial Dysfunction In Vitro

H Mahoney, FC da Silva Junior, C Roberts… - … & Technology Letters, 2022 - ACS Publications
N-(1, 3-Dimethylbutyl)-N′-phenyl-p-phenylenediamine-quinone (6PPD-quinone), a rubber
tire oxidation product found in road runoff, is highly and acutely toxic to selected salmonids …

Analysis, environmental occurrence, fate and potential toxicity of tire wear compounds 6PPD and 6PPD-quinone

X Chen, T He, X Yang, Y Gan, X Qing, J Wang… - Journal of Hazardous …, 2023 - Elsevier
Abstract Tire wear compounds N-(1, 3-dimethylbutyl)-N′-phenyl-p-phenylenediamine
(6PPD) and its derivative 6PPD-quinone have been considered as emerging pollutants and …