Development of a highly efficient long-acting cocaine hydrolase entity to accelerate cocaine metabolism
It is particularly challenging to develop a truly effective pharmacotherapy for cocaine use
disorder (CUD) treatment. Accelerating cocaine metabolism via hydrolysis at cocaine …
disorder (CUD) treatment. Accelerating cocaine metabolism via hydrolysis at cocaine …
Development of Fc-fused cocaine hydrolase for cocaine addiction treatment: catalytic and pharmacokinetic properties
Cocaine abuse is a worldwide public health and social problem without a US Food and
Drug Administration (FDA)-approved medication. Accelerating cocaine metabolism that …
Drug Administration (FDA)-approved medication. Accelerating cocaine metabolism that …
Effects of a cocaine hydrolase engineered from human butyrylcholinesterase on metabolic profile of cocaine in rats
Accelerating cocaine metabolism through enzymatic hydrolysis at cocaine benzoyl ester is
recognized as a promising therapeutic approach for cocaine abuse treatment. Our more …
recognized as a promising therapeutic approach for cocaine abuse treatment. Our more …
Development of a long-acting Fc-fused cocaine hydrolase with improved yield of protein expression
Human butyrylcholinesterase (BChE) is known as a safe and effective protein for
detoxification of organophosphorus (OP) nerve agents. Its rationally designed mutants with …
detoxification of organophosphorus (OP) nerve agents. Its rationally designed mutants with …
In vitro and in vivo stability of a highly efficient long-acting cocaine hydrolase
It is recognized as a promising therapeutic strategy for cocaine use disorder to develop an
efficient enzyme which can rapidly convert cocaine to physiologically inactive metabolites …
efficient enzyme which can rapidly convert cocaine to physiologically inactive metabolites …
Catalytic activities of a highly efficient cocaine hydrolase for hydrolysis of biologically active cocaine metabolites norcocaine and benzoylecgonine
Cocaine is a widely abused, hepatotoxic drug without an FDA-approved pharmacotherapy
specific for cocaine addiction or overdose. It is recognized as a promising therapeutic …
specific for cocaine addiction or overdose. It is recognized as a promising therapeutic …
Effectiveness of a cocaine hydrolase for cocaine toxicity treatment in male and female rats
Abstract Development of a truly effective medication for treatment of cocaine abuse has
been a grand challenge. There is no FDA-approved therapeutic agent specific for cocaine …
been a grand challenge. There is no FDA-approved therapeutic agent specific for cocaine …
Reengineering of albumin-fused cocaine hydrolase CocH1 (TV-1380) to prolong its biological half-life
Therapeutic treatment of cocaine toxicity or addiction is a grand medical challenge. As a
promising therapeutic strategy for treatment of cocaine toxicity and addiction to develop a …
promising therapeutic strategy for treatment of cocaine toxicity and addiction to develop a …
Long-acting cocaine hydrolase for addiction therapy
X Chen, L Xue, S Hou, Z Jin, T Zhang… - Proceedings of the …, 2016 - National Acad Sciences
Cocaine abuse is a world-wide public health and social problem without a US Food and
Drug Administration-approved medication. An ideal anticocaine medication would …
Drug Administration-approved medication. An ideal anticocaine medication would …
Long-lasting blocking of interoceptive effects of cocaine by a highly efficient cocaine hydrolase in rats
Cocaine dependence is a serious world-wide public health problem without an FDA-
approved pharmacotherapy. We recently designed and discovered a highly efficient long …
approved pharmacotherapy. We recently designed and discovered a highly efficient long …