Impact of proton pump inhibitor use on the effectiveness of immune checkpoint inhibitors in advanced cancer patients
Background: The gut microbiome plays a critical role in modulating the therapeutic effect of
immune checkpoint inhibitors (ICIs). Proton pump inhibitors (PPIs) are commonly used in …
immune checkpoint inhibitors (ICIs). Proton pump inhibitors (PPIs) are commonly used in …
Effects of concomitant proton pump inhibitor use on immune checkpoint inhibitor efficacy among patients with advanced cancer
BD Qin, XD Jiao, XC Zhou, B Shi, J Wang, K Liu… - …, 2021 - Taylor & Francis
Background The present study aimed to evaluate the effects of concomitant proton pump
inhibitor (PPI) use on immune checkpoint inhibitor (ICI) efficacy among advanced cancer …
inhibitor (PPI) use on immune checkpoint inhibitor (ICI) efficacy among advanced cancer …
The association between proton pump inhibitors use and clinical outcome of patients receiving immune checkpoint inhibitors therapy
M Li, C Zeng, J Yao, Y Ge, G An - International Immunopharmacology, 2020 - Elsevier
Background The gut microbiome can mediate the efficacy of immune checkpoint inhibitors
(ICI). Meanwhile, proton pump inhibitors (PPI) can modulate the gut microbiome …
(ICI). Meanwhile, proton pump inhibitors (PPI) can modulate the gut microbiome …
Association of proton pump inhibitor use with survival outcomes in cancer patients treated with immune checkpoint inhibitors: a systematic review and meta-analysis
B Chen, C Yang, MP Dragomir, D Chi… - Therapeutic …, 2022 - journals.sagepub.com
Background: Proton pump inhibitors (PPIs) have been shown to regulate the gut microbiome
and affect the response to immune checkpoint inhibitors (ICIs). Contradictory results on …
and affect the response to immune checkpoint inhibitors (ICIs). Contradictory results on …
[HTML][HTML] The effect of proton pump inhibitor uses on outcomes for cancer patients treated with immune checkpoint inhibitors: a meta-analysis
C Li, Z Xia, A Li, J Meng - Annals of Translational Medicine, 2020 - ncbi.nlm.nih.gov
Background Proton pump inhibitors (PPIs) are commonly prescribed for preventing and
treating gastrointestinal ulcers. In patients with advanced cancer, it is unclear whether …
treating gastrointestinal ulcers. In patients with advanced cancer, it is unclear whether …
[HTML][HTML] Do proton pump inhibitors alter the response to immune checkpoint inhibitors in cancer patients? A meta-analysis
S Lopes, L Pabst, A Dory, M Klotz, B Gourieux… - Frontiers in …, 2023 - frontiersin.org
Introduction Gut microbiota can significantly affect the effectiveness of immune checkpoint
inhibitors (ICIs) in cancer patients. Recently, antibiotics were shown to decrease survival …
inhibitors (ICIs) in cancer patients. Recently, antibiotics were shown to decrease survival …
Proton pump inhibitors and response to immune check-point inhibitors: Single center study.
A Trabolsi, M Winter, E Rodriguez - 2019 - ascopubs.org
e14092 Background: Checkpoint inhibitors (blocking antibodies to PD-1, PD-L1, CTLA-4)
have proven effective against several tumor types. While the response is impressive in some …
have proven effective against several tumor types. While the response is impressive in some …
[HTML][HTML] An up-to-date investigation into the correlation between proton pump inhibitor use and the clinical efficacy of immune checkpoint inhibitors in advanced solid …
C Liu, H Guo, H Mao, J Tong, M Yang, X Yan - Frontiers in Oncology, 2022 - frontiersin.org
Background Although immune checkpoint inhibitors (ICIs) have revolutionized the current
anticancer therapies, a considerable proportion of patients are found to hardly benefit from …
anticancer therapies, a considerable proportion of patients are found to hardly benefit from …
[HTML][HTML] The association between baseline proton pump inhibitors, immune checkpoint inhibitors, and chemotherapy: a systematic review with network meta-analysis
Y Chang, WY Lin, YC Chang, CH Huang, HE Tzeng… - Cancers, 2022 - mdpi.com
Simple Summary Proton pump inhibitors (PPIs) are the most commonly used gastric acid
suppressants in cancer patients. However, long-term use of PPIs can cause dysbiosis effects …
suppressants in cancer patients. However, long-term use of PPIs can cause dysbiosis effects …
[HTML][HTML] Impact of antibiotics and proton pump inhibitors on efficacy and tolerance of anti-PD-1 immune checkpoint inhibitors
Q Giordan, J Salleron, C Vallance, C Moriana… - Frontiers in …, 2021 - frontiersin.org
Background The use of antibiotics (ATB) and proton-pump inhibitors (PPI) alters the
composition and diversity of the gut microbiota, which can influence the immune system …
composition and diversity of the gut microbiota, which can influence the immune system …