Abstract Interleukin-12 (IL-12) and interleukin-23 (IL-23), which belong to the IL-12 family of
cytokines, have a key role in intestinal homeostasis and inflammation and are implicated in …

Abstract The interleukin (IL)-12/IL-23 pathway is one of many proposed mechanistic
pathways of intestinal inflammation. Earlier studies introduced IL-12 as a major cytokine in …

The inflammatory bowel diseases (IBDs) are chronic immune-mediated inflammatory
disorders, including ulcerative colitis (UC) and Crohn's disease (CD). IBD results from a …

Abstract The interleukin-23 [IL-23] cytokine, derived predominantly from macrophages and
dendritic cells in response to microbial stimulation, has emerged as a critical promoter of …

Summary Interleukin-23 (IL-23) and IL-17 are cytokines currently being targeted in clinical
trials. Although inhibition of both of these cytokines is effective for treating psoriasis, IL-12 …

Crohn's disease (CD) and ulcerative colitis (UC) are chronic inflammatory disorders of the
gastrointestinal tract that share clinical and pathological characteristics. The most accredited …

Studies in recent years have identified a pivotal role of the cytokine IL-23 in the
pathogenesis of inflammatory bowel diseases (IBD: Crohn´ s disease, ulcerative colitis) and …

Insights into the pathogenesis of inflammatory bowel diseases (IBDs) have provided
important information for the development of therapeutics. Levels of interleukin 23 (IL23) and …

The etiology of inflammatory bowel disease is unknown but available evidence suggests
that a deregulated immune response towards the commensal bacterial flora is responsible …

Abstract IL-12 and IL-23 are closely related cytokines with important roles in the regulation of
tissue inflammation. Converging evidence from studies in mice, human observational …