Bridging the species gap in translational research for neurodevelopmental disorders

AM Ryan, RF Berman, MD Bauman - Neurobiology of learning and …, 2019 - Elsevier
The prevalence and societal impact of neurodevelopmental disorders (NDDs) continue to
increase despite years of research in both patient populations and animal models. There …

Improving treatment of neurodevelopmental disorders: recommendations based on preclinical studies

JR Homberg, EJ Kyzar, AM Stewart… - Expert opinion on …, 2016 - Taylor & Francis
Introduction: Neurodevelopmental disorders (NDDs) are common and severely debilitating.
Their chronic nature and reliance on both genetic and environmental factors makes studying …

Reversing neurodevelopmental disorders in adults

D Ehninger, W Li, K Fox, MP Stryker, AJ Silva - Neuron, 2008 - cell.com
Abnormalities in brain development, thought to be irreversible in adults, have long been
assumed to underlie the neurological and psychiatric symptoms associated with …

Understanding autism and other neurodevelopmental disorders through experimental translational neurobehavioral models

JR Homberg, EJ Kyzar, M Nguyen, WH Norton… - Neuroscience & …, 2016 - Elsevier
Neurodevelopmental disorders (NDDs) are highly prevalent and severely debilitating brain
illnesses caused by aberrant brain growth and development. Resulting in cognitive, social …

Genetic and environmental modulation of neurodevelopmental disorders: translational insights from labs to beds

JR Homberg, EJ Kyzar, ML Scattoni, WH Norton… - Brain research …, 2016 - Elsevier
Neurodevelopmental disorders (NDDs) are a heterogeneous group of prevalent
neuropsychiatric illnesses with various degrees of social, cognitive, motor, language and …

Neurodevelopmental Disorders, Causes, and Consequences

EH Sherr - Genomics, Circuits, and Pathways in Clinical …, 2016 - Elsevier
In the overlap between the fields of neurology, psychiatry, and pediatrics, it may be hard to
find a term with as much generality as neurodevelopmental disorders (NDD). Not …

Genetic rodent models of brain disorders: Perspectives on experimental approaches and therapeutic strategies

CM McGraw, CS Ward… - American Journal of …, 2017 - Wiley Online Library
Neurobehavioral disorders comprised of neurodegenerative, neurodevelopmental, and
psychiatric disorders together represent leading causes of morbidity and mortality. Despite …

The clinical-basic interface in defining pathogenesis in disorders of neurodevelopmental origin

BL Thompson, P Levitt - Neuron, 2010 - cell.com
Human cognitive and social-emotional behaviors are heterogeneous, underscoring the
challenges in modeling pathogenesis in disorders of neurodevelopmental origin in which …

Modelling behaviors relevant to brain disorders in the nonhuman primate: Are we there yet?

JT Scott, JA Bourne - Progress in Neurobiology, 2022 - Elsevier
Recent years have seen a profound resurgence of activity with nonhuman primates (NHPs)
to model human brain disorders. From marmosets to macaques, the study of NHP species …

Zebrafish as a model of neurodevelopmental disorders

MS De Abreu, R Genario, ACVV Giacomini, KA Demin… - Neuroscience, 2020 - Elsevier
Neurodevelopmental disorders (NDDs) caused by aberrant brain growth and development
are life-long, debilitating illnesses that markedly impair the quality of life. Animal models are …