[HTML][HTML] Inhibitors of mammalian aquaporin water channels
Aquaporins (AQPs) are water channel proteins that are essential to life, being expressed in
all kingdoms. In humans, there are 13 AQPs, at least one of which is found in every organ …
all kingdoms. In humans, there are 13 AQPs, at least one of which is found in every organ …
Aquaporins as targets for drug discovery
The intracellular hydric balance is an essential process of mammalian cells. The water
movement across cell membranes is driven by osmotic and hydrostatic forces and the speed …
movement across cell membranes is driven by osmotic and hydrostatic forces and the speed …
Aquaporins in drug discovery and pharmacotherapy
VJ Huber, M Tsujita, T Nakada - Molecular aspects of medicine, 2012 - Elsevier
Identification of the aquaporin (AQP) protein family more than twenty years ago has ushered
in an era where water and neutral solute trafficking is considered a prime target for …
in an era where water and neutral solute trafficking is considered a prime target for …
Roles for novel pharmacological blockers of aquaporins in the treatment of brain oedema and cancer
AJ Yool, EA Brown, GA Flynn - Clinical and Experimental …, 2010 - Wiley Online Library
Aquaporins (AQPs) are targets for drug discovery for basic research and medicine. Human
diseases involving fluid imbalances and oedema are of major concern and involve tissues in …
diseases involving fluid imbalances and oedema are of major concern and involve tissues in …
Aquaporins: a promising target for drug development
K Jeyaseelan, S Sepramaniam… - Expert opinion on …, 2006 - Taylor & Francis
Aquaporins (AQPs) are a family of small hydrophobic, integral membrane proteins that are
expressed in all living organisms and play critical roles in controlling the water flow into and …
expressed in all living organisms and play critical roles in controlling the water flow into and …
Aquaporins: important but elusive drug targets
AS Verkman, MO Anderson… - Nature reviews Drug …, 2014 - nature.com
The aquaporins (AQPs) are a family of small, integral membrane proteins that facilitate water
transport across the plasma membranes of cells in response to osmotic gradients. Data from …
transport across the plasma membranes of cells in response to osmotic gradients. Data from …
Aquaporin modulators: a patent review (2010–2015)
Introduction: Since the discovery of aquaporin-1 (AQP1) as a water channel, more than
2,000 articles, reviews and chapters have been published. The wide tissue expression …
2,000 articles, reviews and chapters have been published. The wide tissue expression …
Aquaporins as potential drug targets
F Wang, X Feng, Y Li, H Yang, T Ma - Acta Pharmacologica Sinica, 2006 - nature.com
The aquaporins (AQP) are a family of integral membrane proteins that selectively transport
water and, in some cases, small neutral solutes such as glycerol and urea. Thirteen …
water and, in some cases, small neutral solutes such as glycerol and urea. Thirteen …
The aquaporin-4 water channel as a potential drug target in neurological disorders
AS Verkman, AJ Smith, P Phuan… - Expert opinion on …, 2017 - Taylor & Francis
ABSTRACT Introduction: Aquaporin-4 (AQP4) is a water transporting protein expressed at
the plasma membrane of astrocytes throughout the central nervous system (CNS). Analysis …
the plasma membrane of astrocytes throughout the central nervous system (CNS). Analysis …
Challenges and achievements in the therapeutic modulation of aquaporin functionality
E Beitz, A Golldack, M Rothert, J von Buelow - Pharmacology & …, 2015 - Elsevier
Aquaporin (AQP) water and solute channels have basic physiological functions throughout
the human body. AQP-facilitated water permeability across cell membranes is required for …
the human body. AQP-facilitated water permeability across cell membranes is required for …