[HTML][HTML] Cardiovascular adverse events in oncology trials: understanding and appreciating the differences between clinical trial data and real-world reports
MS Ewer, J Herson - Cardio-Oncology, 2022 - Springer
Reports of cardiac adverse events from oncology clinical trials often are at variance with
reports derived from clinical observations or data-base reviews. These differences may lead …
reports derived from clinical observations or data-base reviews. These differences may lead …
[HTML][HTML] Pumping Up the Standards: A Call for Improved Cardiovascular Event Reporting in Oncology Trials
C Kappel, H Abdel-Qadir, MB Nadler - Cardio Oncology, 2024 - jacc.org
Cardiovascular disease (CVD) is the leading competing cause of mortality in patients with
cancer. 1 Cancer and CVD have shared risk factors that independently increase the …
cancer. 1 Cancer and CVD have shared risk factors that independently increase the …
[HTML][HTML] Adverse cardiovascular events in cancer trials: missing in action?
NH Bishopric, ME Lippman - Journal of the American College of …, 2020 - jacc.org
cardiotoxins, including anthracyclines, erb-b2–targeting agents, and chest radiation are
widely used in breast cancer and other malignancies, and observational data suggest that …
widely used in breast cancer and other malignancies, and observational data suggest that …
Reporting of cardiovascular events in clinical trials supporting FDA approval of contemporary cancer therapies
Background Cardiovascular disease (CVD) has become an increasingly common limitation
to effective anticancer therapy. Yet, whether CVD events were consistently reported in …
to effective anticancer therapy. Yet, whether CVD events were consistently reported in …
Cardiovascular safety of oncologic agents: a double-edged sword even in the era of targeted therapies–part 1
AA Manolis, TA Manolis, DP Mikhailidis… - Expert Opinion on …, 2018 - Taylor & Francis
Introduction: Patients with cancer are subject to the cardiotoxic effects of cancer therapy and
as more patients survive cancer due to improved treatment they are exposed to various …
as more patients survive cancer due to improved treatment they are exposed to various …
Cardiovascular safety assessment in cancer drug development
O Oren, TG Neilan, MG Fradley… - Journal of the American …, 2021 - Am Heart Assoc
The development of cardiovascular toxicity attributable to anticancer drugs is a pivotal event
that is associated with cardiovascular morbidity as well as with worse cancer‐specific and …
that is associated with cardiovascular morbidity as well as with worse cancer‐specific and …
Cardiovascular safety of oncologic agents: a double-edged sword even in the era of targeted therapies–Part 2
AA Manolis, TA Manolis, DP Mikhailidis… - Expert Opinion on …, 2018 - Taylor & Francis
Introduction: Patients with cancer are subject to the cardiotoxic effects of cancer therapy.
Improved cancer treatments lead to more cancer-survivors, who though are exposed to …
Improved cancer treatments lead to more cancer-survivors, who though are exposed to …
Cancer in cardiovascular drug trials and vice versa: a personal perspective
MA Pfeffer - European heart journal, 2013 - academic.oup.com
Acknowledging uncertainties and balancing the opportunity for benefit with the offsetting
potential to harm are integral concepts for clinical decision-making. Caregivers consciously …
potential to harm are integral concepts for clinical decision-making. Caregivers consciously …
Cardiovascular safety communications after US Food and Drug Administration approval of contemporary cancer therapies
JM Bonsu, O Kola-Kehinde, L Kim, P Ruz… - JAMA …, 2021 - jamanetwork.com
Methods| Leveraging the Drugs@ FDA database, and publicly available FDA drug reviews,
we manually identified all anticancer drugs and biologics given new drug applications by the …
we manually identified all anticancer drugs and biologics given new drug applications by the …
Cardiovascular toxicity related to cancer treatment: a pragmatic approach to the American and European cardio‐oncology guidelines
J Alexandre, J Cautela, S Ederhy… - Journal of the …, 2020 - Am Heart Assoc
The considerable progress made in the field of cancer treatment has led to a dramatic
improvement in the prognosis of patients with cancer. However, toxicities resulting from …
improvement in the prognosis of patients with cancer. However, toxicities resulting from …