[HTML][HTML] Cardiovascular adverse events in oncology trials: understanding and appreciating the differences between clinical trial data and real-world reports

MS Ewer, J Herson - Cardio-Oncology, 2022 - Springer
Reports of cardiac adverse events from oncology clinical trials often are at variance with
reports derived from clinical observations or data-base reviews. These differences may lead …

[HTML][HTML] Pumping Up the Standards: A Call for Improved Cardiovascular Event Reporting in Oncology Trials

C Kappel, H Abdel-Qadir, MB Nadler - Cardio Oncology, 2024 - jacc.org
Cardiovascular disease (CVD) is the leading competing cause of mortality in patients with
cancer. 1 Cancer and CVD have shared risk factors that independently increase the …

[HTML][HTML] Adverse cardiovascular events in cancer trials: missing in action?

NH Bishopric, ME Lippman - Journal of the American College of …, 2020 - jacc.org
cardiotoxins, including anthracyclines, erb-b2–targeting agents, and chest radiation are
widely used in breast cancer and other malignancies, and observational data suggest that …

Reporting of cardiovascular events in clinical trials supporting FDA approval of contemporary cancer therapies

JM Bonsu, A Guha, L Charles, VO Yildiz, L Wei… - Journal of the American …, 2020 - jacc.org
Background Cardiovascular disease (CVD) has become an increasingly common limitation
to effective anticancer therapy. Yet, whether CVD events were consistently reported in …

Cardiovascular safety of oncologic agents: a double-edged sword even in the era of targeted therapies–part 1

AA Manolis, TA Manolis, DP Mikhailidis… - Expert Opinion on …, 2018 - Taylor & Francis
Introduction: Patients with cancer are subject to the cardiotoxic effects of cancer therapy and
as more patients survive cancer due to improved treatment they are exposed to various …

Cardiovascular safety assessment in cancer drug development

O Oren, TG Neilan, MG Fradley… - Journal of the American …, 2021 - Am Heart Assoc
The development of cardiovascular toxicity attributable to anticancer drugs is a pivotal event
that is associated with cardiovascular morbidity as well as with worse cancer‐specific and …

Cardiovascular safety of oncologic agents: a double-edged sword even in the era of targeted therapies–Part 2

AA Manolis, TA Manolis, DP Mikhailidis… - Expert Opinion on …, 2018 - Taylor & Francis
Introduction: Patients with cancer are subject to the cardiotoxic effects of cancer therapy.
Improved cancer treatments lead to more cancer-survivors, who though are exposed to …

Cancer in cardiovascular drug trials and vice versa: a personal perspective

MA Pfeffer - European heart journal, 2013 - academic.oup.com
Acknowledging uncertainties and balancing the opportunity for benefit with the offsetting
potential to harm are integral concepts for clinical decision-making. Caregivers consciously …

Cardiovascular safety communications after US Food and Drug Administration approval of contemporary cancer therapies

JM Bonsu, O Kola-Kehinde, L Kim, P Ruz… - JAMA …, 2021 - jamanetwork.com
Methods| Leveraging the Drugs@ FDA database, and publicly available FDA drug reviews,
we manually identified all anticancer drugs and biologics given new drug applications by the …

Cardiovascular toxicity related to cancer treatment: a pragmatic approach to the American and European cardio‐oncology guidelines

J Alexandre, J Cautela, S Ederhy… - Journal of the …, 2020 - Am Heart Assoc
The considerable progress made in the field of cancer treatment has led to a dramatic
improvement in the prognosis of patients with cancer. However, toxicities resulting from …