[HTML][HTML] Proteomic biomarkers of the apnea hypopnea index and obstructive sleep apnea: insights into the pathophysiology of presence, severity, and treatment …

KLJ Cederberg, U Hanif, V Peris Sempere… - International journal of …, 2022 - mdpi.com
Obstructive sleep apnea (OSA), a disease associated with excessive sleepiness and
increased cardiovascular risk, affects an estimated 1 billion people worldwide. The present …

Proteomic biomarkers of sleep apnea

A Ambati, YE Ju, L Lin, AN Olesen, H Koch, JJ Hedou… - Sleep, 2020 - academic.oup.com
Abstract Study Objectives Obstructive sleep apnea (OSA) is characterized by recurrent
partial to complete upper airway obstructions during sleep, leading to repetitive arousals …

Advanced proteomics and cluster analysis for identifying novel obstructive sleep apnea subtypes before and after continuous positive airway pressure therapy

V Kundel, O Cohen, S Khan, M Patel… - Annals of the …, 2023 - atsjournals.org
Rationale Studies have shown elevated inflammatory biomarkers in obstructive sleep apnea
(OSA), but data after continuous positive airway pressure (CPAP) treatment are inconsistent …

Molecular signatures of obstructive sleep apnea in adults: a review and perspective

ES Arnardottir, M Mackiewicz, T Gislason, KL Teff… - Sleep, 2009 - academic.oup.com
The consequences of obstructive sleep apnea (OSA) are largely mediated by chronic
intermittent hypoxia and sleep fragmentation. The primary molecular domains affected are …

[HTML][HTML] The discovery, validation, and function of hypoxia-related gene biomarkers for obstructive sleep apnea

X Wu, Z Pan, W Liu, S Zha, Y Song, Q Zhang… - Frontiers in …, 2022 - frontiersin.org
While there is emerging evidence that hypoxia critically contributes to the pathobiology of
obstructive sleep apnea (OSA), the diagnostic value of measuring hypoxia or its surrogates …

Current and future strategies for diagnostic and management of obstructive sleep apnea

S Khurana, N Soda, MJA Shiddiky… - Expert Review of …, 2021 - Taylor & Francis
Introduction Obstructive sleep apnea (OSA) is a common sleep disorder with multiple
comorbidities including hypertension, diabetes, and cardiovascular disorders. Detected …

Overview of proteomics studies in obstructive sleep apnea

A Feliciano, VM Torres, F Vaz, AS Carvalho… - Sleep medicine, 2015 - Elsevier
Obstructive sleep apnea (OSA) is an underdiagnosed common public health concern
causing deleterious effects on metabolic and cardiovascular health. Although much has …

Whole blood hypoxia-related gene expression reveals novel pathways to obstructive sleep apnea in humans

JC Perry, C Guindalini, L Bittencourt, S Garbuio… - Respiratory Physiology …, 2013 - Elsevier
In this study, our goal was to identify the key genes that are associated with obstructive sleep
apnea (OSA). Thirty-five volunteers underwent full in-lab polysomnography and, according …

Advances and challenges in pursuing biomarkers for obstructive sleep apnea: implications for the cardiovascular risk

A Lebkuchen, LS Freitas, KHM Cardozo… - Trends in cardiovascular …, 2021 - Elsevier
Obstructive sleep apnea (OSA) is a common clinical condition associated with increased
cardiovascular morbidity and mortality. Recent evidence from clinical studies and animal …

[HTML][HTML] Whole blood gene expression signature in patients with obstructive sleep apnea and effect of continuous positive airway pressure treatment

E Christensson, S Mkrtchian, A Ebberyd… - Respiratory Physiology …, 2021 - Elsevier
The molecular mechanisms of obstructive sleep apnea (OSA), in particular the gene
expression patterns in whole blood of patients with OSA, can shed more light on the …