Cellular redox homeostasis is an essential, dynamic process that ensures the balance
between reducing and oxidizing reactions within cells and thus has implications across all …

Redox homeostasis is a lifelong pursuit of cancer cells. Depending on the context, reactive
oxygen species (ROS) exert paradoxical effects on cancers; an appropriate concentration …

Reactive oxygen species (ROS) can initiate cancer, but oxidant generation in tumors leaves
them vulnerable to further stresses. In this issue of Cancer Cell, Harris and colleagues show …

Significance: For a healthy cell to turn into a cancer cell and grow out to become a tumor, it
needs to undergo a series of complex changes and acquire certain traits, summarized as …

An unanswered question in human health is whether antioxidation prevents or promotes
cancer. Antioxidation has historically been viewed as chemopreventive, but emerging …

Historically, it has been assumed that oxidative stress contributes to tumor initiation and
progression solely by inducing genomic instability. Recent studies indicate that reactive …

Significance: Increasing evidence indicates that cancer development and progression are
promoted by the joint action of redox distress and inflammation, supporting the potential …

Reactive oxygen species and tumor biology are intertwined in a complex web, making it
difficult to understand which came first, whether oxidants are required for tumor cell growth …

Significance: Cancer is related to redox biology from many points of view, such as initiation
and promotion, metabolism and growth, invasion and metastasis, vascularization, or through …

Reactive oxygen species (ROS) and their products are components of cell signaling
pathways and play important roles in cellular physiology and pathophysiology. Under …