During the past 10 years, the intense involvement of the grey matter of the CNS in the
pathology of multiple sclerosis has become evident. On gross inspection, demyelination in …

Multiple sclerosis (MS) has been classically regarded as a white matter disease. However,
recent histopathological studies have convincingly shown that grey matter regions are also …

Traditionally, multiple sclerosis has been viewed as a disease predominantly affecting white
matter. However, this view has lately been subject to numerous changes, as new evidence …

In patients with multiple sclerosis (MS), grey matter damage is widespread and might
underlie many of the clinical symptoms, especially cognitive impairment. This relation …

Background Demyelination of cerebral white matter is thought to drive neuronal
degeneration and permanent neurological disability in individuals with multiple sclerosis …

Background and Objectives There is currently no consensus about the extent of gray matter
(GM) atrophy that can be attributed to secondary changes after white matter (WM) lesions or …

At the early onset of the 20 th century, several studies already reported that the gray matter
was implicated in the histopathology of multiple sclerosis (MS). However, as white matter …

Although multiple sclerosis (MS) has been considered a white matter disease, MS lesions
are known to occur in grey matter. Recent immunohistochemical studies have demonstrated …

Background: Although grey matter damage in multiple sclerosis is currently recognized,
determinants of grey matter volume and its relationship with disability are not yet clear …

Although multiple sclerosis has traditionally been considered a white matter disease,
extensive research documents the presence and importance of grey matter injury including …