The antiphospholipid (aPL) syndrome is an autoimmune condition that is marked by
recurrent pregnancy losses and/or systemic vascular thrombosis in patients who have …

The mechanism (s) for thrombosis and pregnancy losses in the anti-phospholipid antibody
syndrome have not yet been established. Annexin-V is an anionic phospholipid-binding …

Abstract Annexin A5 (A5) forms 2-dimensional crystals over phospholipid bilayers, blocking
their availability for coagulation reactions. Recently, human antiphospholipid (aPL) …

Annexin A5 (AnxA5) binds to phospholipid bilayers, forming two-dimensional crystals that
block the phospholipids from availability for coagulation enzyme reactions. Antiphospholipid …

The antiphospholipid (aPL) syndrome is a condition that manifests in patients as vascular
thromboembolism or recurrent pregnancy loss together with laboratory evidence for the …

Annexin V, an intracellular protein with a calcium-dependent high affinity for anionic
phospholipid membranes, acts as an inhibitor of lipid-dependent reactions of the blood …

Background The mechanisms of vascular thrombosis and pregnancy loss in the
antiphospholipid-antibody syndrome are unknown. Levels of annexin V, a phospholipid …

The antiphospholipid syndrome is a thrombophilic condition marked by antibodies that
recognize anionic phospholipid-protein cofactor complexes. We recently reported that …

The phospholipid binding protein, annexin A5 (AnxA5), has potent anticoagulant properties
that result from its forming 2-dimensional crystals over phospholipids, blocking the …

OBJECTIVE: Antibody-mediated disruption of the annexin A5 anticoagulant shield has been
posited to be a thrombogenic mechanism in the antiphospholipid syndrome. We recently …