High-mobility group box 1 (HMGB1) is one of the most abundant proteins in eukaryotes and
the best characterized damage-associated molecular pattern (DAMP). The biological …

High mobility group box 1 (HMGB1) is a ubiquitous nuclear protein involved in transcription
regulation, DNA replication and repair and nucleosome assembly. HMGB1 is passively …

Significance: Cardiovascular disease (CVD) is the leading cause of mortality worldwide.
Accumulating evidence shows that dysregulated immune response contributes to several …

High mobility group box 1 (HMGB1) is constitutively expressed by many cells. In cells,
HMGB1 is a transcription factor or transcription enhancer that is involved in nucleosome …

HMGB1 has been formerly known for its intracellular function–as the intranuclear non-
histone DNA binding protein, which contributes to stabilization of nucleosomes, mediation of …

Aims HMGB1 injection into the mouse heart, acutely after myocardial infarction (MI),
improves left ventricular (LV) function and prevents remodeling. Here, we examined the …

High‐mobility group box 1 (HMGB1) is originally identified as a DNA‐binding protein that
functions as a structural co‐factor critical for proper transcriptional regulation in somatic …

Abstract High Mobility Group Box 1 protein was discovered as a nuclear protein, but it has
a⿿ second life⿿ outside the cell where it acts as a damage-associated molecular pattern …

High-mobility group box 1 (HMGB1) is an abundant architectural chromosomal protein that
has multiple biologic functions: gene transcription, DNA replication, DNA-damage repair …

High-mobility group box-1 (HMGB1) is a nuclear protein that acts as a cytokine when
released into the extracellular milieu by necrotic and inflammatory cells, and is involved in …