Statins, typically used to reduce lipid levels, have been rediscovered for exhibiting
anticancer activities. Among them, especially simvastatin may influence the proliferation …

Simple Summary Statins are crucial for managing lipid disorders by inhibiting HMG-CoA
reductase, reducing cholesterol levels, and lowering cardiovascular disease risk. Beyond …

The widespread clinical use of statins has contributed to significant reductions of
cardiovascular morbidity and mortality. Increasing preclinical and epidemiological …

Numerous and different types of cancers possess the dysregulation of the mevalonate
pathway as a common feature. Statins, traditionally applied in cardiovascular diseases to …

Statins are well known competitive inhibitors of hydroxymethylglutaryl-CoA reductase
enzyme (HMG-CoA reductase), thus traditionally used as cholesterol-lowering agents. In …

Abstract Statins, 3-hydroxy-3-methylglutaryl-coenzyme A reductase inhibitors are commonly
used drugs in the treatment of dyslipidemias, primarily raised cholesterol. Recently, many …

Statins, among the most commonly prescribed drugs worldwide, are cholesterol-lowering
agents used to manage and prevent cardiovascular and coronary heart diseases. Recently …

Statins are inhibitors of 3-hydroxy-methylglutaryl (HMG) CoA reductase. They exhibit effects
beyond cholesterol reduction, including anticancer activity. This review presents the effects …

As competitive HMG-CoA reductase (HMGCR) inhibitors, statins not only reduce cholesterol
and improve cardiovascular risk, but also exhibit pleiotropic effects that are independent of …

Statins, which are competitive inhibitors of 3-hydroxy-3-methyl-glutaryl-coenzyme A
reductase, reduce cholesterol blood levels and the risk of developing cardiovascular …