The activation of the pyrin inflammasome represents a highly intriguing mechanism
employed by the innate immune system to effectively counteract pathogenic agents. Despite …

Numerous pathogens including Clostridium difficile and Yersinia pestis have evolved toxins
or effectors targeting GTPases from the RhoA subfamily (RhoA/B/C) to inhibit or hijack the …

Pyrin is a cytosolic protein encoded by the MEFV gene, predominantly expressed in innate
immune cells. Upon activation, it forms an inflammasome, a multimolecular complex that …

Abstract Familial Mediterranean Fever (FMF) is the most common monogenic
autoinflammatory disorder. FMF is caused by mutations in the MEFV gene, encoding pyrin …

The pyrin inflammasome has evolved as an innate immune sensor to detect bacterial toxin-
induced Rho guanosine triphosphatase (Rho GTPase)-inactivation, a process that is similar …

Pyrin, encoded by the MEFV gene, is an intracellular pattern recognition receptor that
assembles inflammasome complexes in response to pathogen infections. Mutations in the …

Human pyrin with gain-of-function mutations in its B30. 2/SPRY domain causes the
autoinflammatory disease familial Mediterranean fever by assembling an ASC-dependent …

The PYRIN inflammasome pathway is part of the innate immune response against invading
pathogens. Unprovoked continuous activation of the PYRIN inflammasome drives …

The pyrin inflammasome acts as a guard of RhoA GTPases and is central to immune
defenses against RhoA-manipulating pathogens. Pyrin activation proceeds in two steps. Yet …

Pyrin is a pattern-recognition receptor in phagocytes that triggers caspase-1 inflammasome
assembly in response to bacterial toxins and effectors that inactivate RhoA. Pyrin contains …