Although chronic myeloid leukemia is a rare malignancy, it has developed into a model
system for the study of a variety of aspects of cancer biology and immunology. The …

Immunoprophylaxis against numerous infectious pathogens represents one of the most
striking and successful medical strategies discovered in the twentieth century. In contrast …

In spite of the considerable successes that have been achieved in the treatment of chronic
myeloid leukemia (CML), cure for the disease can only be obtained by the present means in …

In view of the increasing interest in the immunotherapy of CML it seems highly desirable to
broaden the present knowledge on the immune reactivity of CML patients. A group of 24 …

Background Chronic mye-logenous leukemia (CML) has long been recognized as an entity
responsive to immunotherapeutic interventions. Despite the success of the tyrosine kinase …

Chronic myeloid leukemia (CML) is a clonal bone marrow stem cell neoplasia known to be
responsive to immunotherapy. Despite the success of tyrosine kinase inhibitors (TKIs) …

Abstract Treatment with imatinib mesylate and other tyrosine kinase inhibitors (TKI)
revolutionized the therapy of chronic myeloid leukemia (CML). However, it alone does not …

The negative impact of donor marrow T lymphocyte depletion on relapse of chronic myeloid
leukaemia (CML) following bone marrow transplantation strongly suggests that the …

Chronic myelogenous leukemia is one of the more responsive leukemic disorders to
immunotherapy. Interferon-based regimens were the first treatment to produce complete …

Various clinical and laboratory observations suggest that the leukaemia cells in chronic
myeloid leukaemia (CML) are potentially immunogenic. Whilst the ability of the leukaemia …