Physical activity is a strong stimulus influencing the overall physiology of the human body.
Exercises lead to biochemical changes in various tissues and exert an impact on gene …

The response to exercise training (trainability) has been shown to have a strong heritable
component. There is growing evidence suggesting that traits such as trainability do not only …

Studies investigating the effect of exercise on DNA methylation in human tissues are starting
to emerge. However, as the epigenome differs between cell types [2], the number of …

Epigenetic mechanisms are implicated in gene regulation and the development of different
diseases. The epigenome differs between cell types and has until now only been …

DNA methylation is a covalent biochemical modification controlling chromatin structure and
gene expression. Exercise elicits gene expression changes that trigger structural and …

Changes in DNA methylation may represent an intermediate step between the environment
and human diseases. Little is known on whether behavioral risk factors may modify gene …

Skeletal muscle is highly plastic and dynamically regulated by the body's physical demands.
This study aimed to determine the plasticity of skeletal muscle DNA methylation in response …

DNA methylation is a major epigenetic modification that controls gene expression in
physiologic and pathologic states. Metabolic diseases such as diabetes and obesity are …

Highlights•Exercise alters the gene expression pattern in multiple tissues.•Regular exercise
can modify the genome-wide DNA methylation pattern in humans.•Regular exercise could …

The adaptive response of skeletal muscle to exercise training is tightly controlled and
therefore requires transcriptional regulation. DNA methylation is an epigenetic mechanism …