Chronic myeloid leukemia (CML) is caused by BCRABL1 in a cell with the biological
potential, intrinsic or acquired, to cause leukemia. This cell is commonly termed the CML …

Chronic myeloid leukemia (CML) is a myeloproliferative disease characterized by the
overproduction of granulocytes, which leads to high white blood cell counts and …

Chronic myeloid leukemia (CML) is a clonal myeloproliferative neoplasm driven by BCR-
ABL1 oncoprotein, which plays a pivotal role in CML pathology, diagnosis, and treatment as …

Recent evidence suggests chronic myeloid leukemia (CML) stem cells are insensitive to
kinase inhibitors and responsible for minimal residual disease in treated patients. We …

Chronic myeloid leukemia (CML) is a clonal myeloproliferative disorder characterized by a
chromosome translocation that generates the Bcr-Abl oncogene encoding a constitutive …

Inhibition of BCR-ABL with kinase inhibitors in the treatment of Philadelphia-positive (Ph+)
chronic myeloid leukemia (CML) is highly effective in controlling but not curing the disease …

Chronic myeloid leukemia (CML) is caused by the acquisition of the tyrosine kinase BCR-
ABL1 in a hemopoietic stem cell, transforming it into a leukemic stem cell (LSC) that self …

Abstract Philadelphia chromosome-positive (Ph+) chronic myeloid leukemia (CML) induced
by the BCR-ABL oncogene is believed to be developed from leukemic stem cells (LSCs) …

For two decades, leukaemia stem cells (LSCs) in chronic myeloid leukaemia (CML) and
acute myeloid leukaemia (AML) have been advanced paradigms for the cancer stem cell …

Although rare, chronic myeloid leukemia (CML) represents an important paradigm for
understanding the molecular events leading to malignant transformation of primitive …