Background and objective Bone loss occurs in several inflammatory diseases because of
chronic persistent inflammation that activates osteoclasts (OCs) to increase bone resorption …

Osteoclasts play a critical role in osteoporosis; thus, inhibiting osteoclastogenesis is a
therapeutic strategy for osteoporosis. Galangin, a natural bioflavonoid extracted from a …

Osteoarthritis (OA) is a chronic degenerative joint disease which is greatly affected by the
inflammatory response triggered by the NF-κB signaling pathway. Alpinetin (APT) is a …

Osteoporosis, a systemic bone disease that is characterized by a reduction in bone mass
and destruction of bone microstructure, is becoming a serious problem worldwide. Bone …

As a critical regulator of bone resorption. osteoclastogenesis is closely associated with
osteoporosis (OP) and commonly induced by receptor activator of nuclear factor-κB ligand …

Inflammatory bone destruction has gradually attracted attention worldwide and has been
observed in several kinds of pathological bone diseases, such as osteoarthritis …

Background and purpose Osteoporosis is characterized by excessive bone resorption due
to enhanced osteoclast activation. Stimulation of nuclear factor of activated T cells 1 …

Bone destruction or osteolysis marked by excessive osteoclastic bone resorption is a very
common medical condition. Identification of agents that can effectively suppress excessive …

Osteoporosis is a major debilitating cause of fractures and decreases the quality of life in
elderly patients. Bone homeostasis is maintained by bone forming osteoblasts and bone …

We investigated the effect of galangin, a natural flavonoid, on osteoclastic bone destruction
in collagen-induced arthritis and examined the molecular mechanisms by which galangin …