[HTML][HTML] Piperine induces apoptosis and autophagy in hsc-3 human oral cancer cells by regulating pi3k signaling pathway

EJ Han, EY Choi, SJ Jeon, SW Lee, JM Moon… - International Journal of …, 2023 - mdpi.com
Currently, therapies for treating oral cancer have various side effects; therefore, research on
treatment methods employing natural substances is being conducted. This study aimed to …

[HTML][HTML] Piperine inhibits cell proliferation and induces apoptosis of human gastric cancer cells by downregulating phosphatidylinositol 3-kinase (PI3K)/Akt pathway

H Chen, H Sheng, Y Zhao, G Zhu - Medical Science Monitor …, 2020 - ncbi.nlm.nih.gov
Piperine Inhibits Cell Proliferation and Induces Apoptosis of Human Gastric Cancer Cells by
Downregulating Phosphatidylinositol 3-Kinase (PI3K)/Akt Pathway - PMC Back to Top Skip to …

Piperine triggers apoptosis of human oral squamous carcinoma through cell cycle arrest and mitochondrial oxidative stress

S Siddiqui, MS Ahamad, A Jafri, M Afzal… - Nutrition and …, 2017 - Taylor & Francis
Piperine is a nitrogenous pungent substance exhibiting multifunctional pharmacological
properties. However, the mechanism underlying its anticancer potential is not well …

Genipin induces autophagy and suppresses cell growth of oral squamous cell carcinoma via PI3K/AKT/MTOR pathway

MB Wei, YL Wu, H Liu, C Xie - Drug Design, Development and …, 2020 - Taylor & Francis
Background Oral squamous cell carcinoma (OSCC) is a common malignant tumor of the
head and neck, and it accounts for more than 90% of oral cancer. Due to high mortality …

Piperine induces apoptosis of lung cancer A549 cells via p53-dependent mitochondrial signaling pathway

Y Lin, J Xu, H Liao, L Li, L Pan - Tumor Biology, 2014 - Springer
The aim of this study was to evaluate the cytotoxic and apoptotic effects of piperine on
human lung cancer A549 cells and to explore its mechanisms. Piperine was found to exert …

Mechanism of piperine in affecting apoptosis and proliferation of gastric cancer cells via ROS‐mitochondria‐associated signalling pathway

L Guo, Y Yang, YJ Sheng, J Wang… - Journal of Cellular …, 2021 - Wiley Online Library
Piperine (PIP), the main active ingredient in pepper, belongs to the cinnamamide alkaloid.
PIP has been found to have functions, including anti‐oxidation, immune regulation, anti …

Piperine inhibits the proliferation of human prostate cancer cells via induction of cell cycle arrest and autophagy

D Ouyang, L Zeng, H Pan, L Xu, Y Wang, K Liu… - Food and chemical …, 2013 - Elsevier
Piperine, an alkaloid from black and long peppers (Piper nigrum Linn & Piper longum Linn),
has been reported to exhibit antitumor activities in vitro and in vivo. To further understand the …

Piperine functions as a tumor suppressor for human ovarian tumor growth via activation of JNK/p38 MAPK-mediated intrinsic apoptotic pathway

L Si, R Yang, R Lin, S Yang - Bioscience Reports, 2018 - portlandpress.com
Piperine, a kind of natural alkaloid found in the fruit of black (Piper nigrum Linn) and long
(Piper longum Linn), has shown antitumor activities toward various cancer cell lines …

[HTML][HTML] Capsaicin induces autophagy and apoptosis in human nasopharyngeal carcinoma cells by downregulating the PI3K/AKT/mTOR pathway

YT Lin, HC Wang, YC Hsu, CL Cho, MY Yang… - International Journal of …, 2017 - mdpi.com
Capsaicin is a potential chemotherapeutic agent for different human cancers. In Southeast
China, nasopharyngeal carcinoma (NPC) has the highest incidence of all cancers, but final …

Molecular Aspects of Piperine in Signaling Pathways Associated with Inflammation in Head and Neck Cancer

JP Gusson-Zanetoni, LP Cardoso… - International Journal of …, 2024 - mdpi.com
Piperine, an active plant alkaloid from black pepper (Piper nigrum), has several
pharmacological effects, namely antioxidant, anti-inflammatory and immunomodulatory …