Development of the mammalian inner ear requires coordination of cell proliferation, cell fate
determination and morphogenetic movements. While significant progress has been made in …

Morphogenesis of sensory hair cells, in particular their mechanotransduction organelle, the
stereociliary bundle, requires highly organized remodeling of the actin cytoskeleton. The …

The inner ear develops from a simple epithelium (otic placode) into the complex structures
specialized for balance (vestibule) and sound (cochlea) detection. Abnormal vestibular and …

Haploinsufficiency of Gata3 causes hypoparathyroidism, deafness and renal dysplasia
(HDR) syndrome in mice and humans. Gata3 null mutation leads to early lethality around …

The small GTP-binding protein Rac1, a member of the Rho family of small GTPases, has
been implicated in regulation of many cellular processes including adhesion, migration and …

Rac GTPases are members of the Rho family regulating the actin cytoskeleton and
implicated in neuronal development. Ubiquitous Rac1 and neuron‐specific Rac3 GTPases …

Rho GTPases are essential regulators of the actin cytoskeleton. They are involved in various
physiological and biochemical processes such as the regulation of cytoskeleton dynamics …

Cell rearrangement, accompanied by the rapid assembly and disassembly of cadherin-
mediated cell adhesions, plays essential roles in epithelial morphogenesis. Various in vitro …

Rac GTPases and their effectors control cellular morphogenesis in a wide range of
developmental contexts by regulating the structure and dynamics of the actin cytoskeleton …

Background Paraxial protocadherin (PAPC) plays a crucial role in morphogenetic
movements during gastrulation and somitogenesis in mouse, zebrafish and Xenopus. PAPC …