The biological effects of interventions to control infectious diseases typically depend on the
intensity of pathogen challenge. As much as the levels of natural pathogen circulation vary …

A long-standing question in infection biology is why two very similar individuals, with very
similar pathogen exposures, may have very different outcomes. Recent experiments have …

The study of infectious disease has been aided by model organisms, which have helped to
elucidate molecular mechanisms and contributed to the development of new treatments; …

Infection is a complex and dynamic process involving a population of invading microbes, the
host and its responses, aimed at controlling the situation. Depending on the purpose and …

How are some individuals surviving infections while others die? The answer lies in how
infected individuals invest into controlling pathogen proliferation and mitigating damage, two …

The ability to tolerate infection is a key component of host defence and offers potential novel
therapeutic approaches for infectious diseases. To yield successful targets for therapeutic …

Many vector-borne diseases lack effective vaccines and medications, and the limitations of
traditional vector control have inspired novel approaches based on using genetic …

The within-host ecology of hosts and their microbes involves complex feedbacks between
the host immune system, energetic resources, and microbial growth and virulence, which in …

Characterizing infectivity as a function of pathogen dose is integral to microbial risk
assessment. Dose-response experiments usually administer doses to subjects at one time …

The lack of effective vaccines for many endemic diseases often forces policymakers to rely
on non-immunizing control measures, such as vector control, to reduce the massive burden …