While a genome‐centric paradigm in human cancer development was useful for the
understanding of some malignancies such as leukemias, causative molecular defects …

Melanoma arises through the accrual of mutations in genes critical for proliferation and
survival. Although melanoma had been traditionally conceptualized as a cell-autonomous …

Tumor cells communicate bidirectionally with the surrounding microenvironment, sending
and receiving topographical and molecular cues that direct diverse cellular phenomena …

An often overlooked facet of tumor biology research is the involvement of the surrounding
tumor microenvironment. Increasing evidence is being presented to support a major role for …

Over the past decade, melanoma has led the field in new cancer treatments, with impressive
gains in on-treatment survival but more modest improvements in overall survival. Melanoma …

Although most melanoma cases may be treated by surgical intervention upon early
diagnosis, a significant portion of patients can still be refractory, presenting low survival rates …

Cutaneous malignant melanomas originate primarily within epidermal melanocytic cells.
Melanoma cells share many characteristics with melanocyte precursors, suggesting that …

Melanoma develops from a series of architectural and phenotypically distinct stages and
becomes progressively aggressive culminating in metastasis. Over the years, considerable …

The acquisition of invasive behaviour is the key transition in the progression of benign
melanocyte hyperplasia to life threatening melanoma. Understanding this transition and the …

In the vertebrate embryo, melanocytes arise from the neural crest, migrate to and colonize
the basal layer within the skin and skin appendages. Post-migratory melanocytes are …