[HTML][HTML] PR-SET7 epigenetically restrains uterine interferon response and cell death governing proper postnatal stromal development

H Bao, Y Sun, N Deng, L Zhang, Y Jia, G Li… - Nature …, 2024 - nature.com
The differentiation of the stroma is a hallmark event during postnatal uterine development.
However, the spatiotemporal changes that occur during this process and the underlying …

[HTML][HTML] PR-Set7 deficiency limits uterine epithelial population growth hampering postnatal gland formation in mice

T Cui, B He, S Kong, C Zhou, H Zhang, Z Ni… - Cell Death & …, 2017 - nature.com
Formation of secretary endometrial glands in the uterus known as adenogenesis is a typical
process of branching morphogenesis involving dynamic epithelial growth and differentiation …

[HTML][HTML] Menin directs regionalized decidual transformation through epigenetically setting PTX3 to balance FGF and BMP signaling

M Liu, W Deng, L Tang, M Liu, H Bao, C Guo… - Nature …, 2022 - nature.com
During decidualization in rodents, uterine stroma undergoes extensive reprograming into
distinct cells, forming the discrete regions defined as the primary decidual zone (PDZ), the …

Trophoblast PR-SET7 dysfunction induces viral mimicry response and necroptosis associated with recurrent miscarriage

X Zhou, Y Xu, S Ren, N Yang, Y Sun… - Proceedings of the …, 2023 - National Acad Sciences
Recurrent miscarriage (RM) is a distressing pregnancy complication. While the etiology of
RM remains unclear, growing evidence has indicated the relevance of trophoblast …

[HTML][HTML] Gene silencing by EZH2 suppresses TGF-β activity within the decidua to avert pregnancy-adverse wound healing at the maternal-fetal interface

I Osokine, J Siewiera, D Rideaux, S Ma, T Tsukui… - Cell reports, 2022 - cell.com
A little-appreciated feature of early pregnancy is that embryo implantation and placental
outgrowth do not evoke wound-healing responses in the decidua, the specialized …

[HTML][HTML] H3K27me3 dynamics dictate evolving uterine states in pregnancy and parturition

P Nancy, J Siewiera, G Rizzuto… - The Journal of …, 2018 - Am Soc Clin Investig
Uncovering the causes of pregnancy complications such as preterm labor requires greater
insight into how the uterus remains in a noncontractile state until term and then surmounts …

[HTML][HTML] Estrogen-induced expression of Fos-related antigen 1 (FRA-1) regulates uterine stromal differentiation and remodeling

A Das, Q Li, MJ Laws, H Kaya, MK Bagchi… - Journal of Biological …, 2012 - ASBMB
Concerted actions of estrogen and progesterone via their cognate receptors orchestrate
changes in the uterine tissue, regulating implantation during early pregnancy. The uterine …

Early growth response 1 transcriptionally primes the human endometrial stromal cell for decidualization

MM Szwarc, L Hai, WE Gibbons, Q Mo, RB Lanz… - The Journal of steroid …, 2019 - Elsevier
Mouse studies support a role for endometrial early growth response 1 (EGR1) in uterine
receptivity and decidualization, which are processes controlled by estrogen and …

H3K27me3 timely dictates uterine epithelial transcriptome remodeling and thus transformation essential for normal embryo implantation

N Deng, G Li, L Zhang, P Wang, M Liu, B He… - Cell Death & …, 2024 - nature.com
Uterine luminal epithelia (LE), the first layer contacting with the blastocyst, acquire receptivity
for normal embryo implantation. Besides the well-accepted transcriptional regulation …

[HTML][HTML] Deciphering a critical role of uterine epithelial SHP2 in parturition initiation at single cell resolution

M Liu, M Ji, J Cheng, Y Li, Y Tian, H Zhao… - Nature …, 2023 - nature.com
The timely onset of female parturition is a critical determinant for pregnancy success. The
highly heterogenous maternal decidua has been increasingly recognized as a vital factor in …