[HTML][HTML] In vitro study of the blood–brain barrier transport of natural compounds recovered from agrifood by-products and microalgae

JD Sánchez-Martínez, AR Garcia… - International Journal of …, 2022 - mdpi.com
Agrifood by-products and microalgae represent a low-cost and valuable source of bioactive
compounds with neuroprotective properties. However, the neuroprotective effectiveness of …

[HTML][HTML] Blood–brain barrier permeability study of potential neuroprotective compounds recovered from plants and agri-food by-products

JD Sánchez-Martínez, A Valdés, R Gallego… - Frontiers in …, 2022 - frontiersin.org
Plants and agri-food by-products represent a wide and renewable source of bioactive
compounds with neuroprotective properties. In this research, various green extraction …

[HTML][HTML] In vitro study of the blood–brain barrier transport of bioactives from Mediterranean foods

M Gallardo-Fernandez, AR Garcia… - Food & Function, 2024 - pubs.rsc.org
The Mediterranean diet (MD), characterized by olive oil, olives, fruits, vegetables, and wine
intake, is associated with a reduced risk of dementia. These foods are rich in bioactives with …

[HTML][HTML] A new frontier in neuropharmacology: Recent progress in natural products research for blood–brain barrier crossing

UV Isabel, ARM Belén, GB Elena - Current Research in Biotechnology, 2024 - Elsevier
Neuropharmacology faces challenges due to the intricate nervous system, diverse
neurological disorders, and existence of the blood–brain barrier (BBB), which hinder the …

Transport of active flavonoids, based on cytotoxicity and lipophilicity: An evaluation using the blood–brain barrier cell and Caco-2 cell models

Y Yang, L Bai, X Li, J Xiong, P Xu, C Guo, M Xue - Toxicology in Vitro, 2014 - Elsevier
This in vitro study aims to evaluate and compare transmembrane transport of eight cardio-
cerebrovascular protection flavonoids including puerarin, rutin, hesperidin, quercetin …

Phenolic compounds that cross the blood–brain barrier exert positive health effects as central nervous system antioxidants

D Velásquez-Jiménez, DA Corella-Salazar… - Food & Function, 2021 - pubs.rsc.org
The blood–brain barrier (BBB) is a physical structure whose main function is to strictly
regulate access to circulating compounds into the central nervous system (CNS). Vegetable …

Blood-brain barrier permeability of asiaticoside, madecassoside and asiatic acid in porcine brain endothelial cell model

NA Hanapi, ASM Arshad, JM Abdullah… - Journal of …, 2021 - Elsevier
Neurotherapeutic potentials of Centella asiatica and its reputation to boost memory, prevent
cognitive deficits and improve brain functions are widely acknowledged. The plant's …

Flavonoid transport across RBE4 cells: A blood-brain barrier model

A Faria, D Pestana, D Teixeira, J Azevedo… - Cellular and Molecular …, 2010 - degruyter.com
There is a growing interest in dietary therapeutic strategies to combat oxidative stress-
induced damage to the Central Nervous System (CNS), which is associated with a number …

Insights into the putative catechin and epicatechin transport across blood-brain barrier

A Faria, D Pestana, D Teixeira, PO Couraud… - Food & function, 2011 - pubs.rsc.org
The identification of mechanisms associated with phenolic neuroprotection is delayed due to
a lack of information regarding the ability of phenolic compounds to enter the central …

Rapid screening of brain-penetrable antioxidants from natural products by blood-brain barrier specific permeability assay combined with DPPH recognition

J Zhu, X Yi, J Zhang, S Chen, Y Wu - Journal of Pharmaceutical and …, 2018 - Elsevier
Screening brain-penetrable antioxidants from natural products is a promising way for
neuroprotective drug discovery. However, there is no screening methodology enables …