Paul-Alain Jaffrès a, e, Consuelo Gajate b, Ana Maria Bouchet c, e, Hélène Couthon-
Gourvès a, e, Aurélie Chantôme c, e, Marie Potier-Cartereau c, e, Pierre Besson c, e …

Synthetic alkyl lipids, such as the ether lipids edelfosine (1-O-octadecyl-2-O-methyl-rac-
glycero-3-phosphocholine) and ohmline (1-O-hexadecyl-2-O-methyl-rac-glycero-3-β …

Edelfosine (1-O-octadecyl-2-O-methyl-sn-glycero-phosphocholine) and miltefosine (
hexadecylphosphocholine) are synthetic alkylphospholipids (ALPs) that are reported to …

Cell signaling does not apparently occur randomly over the cell surface, but it seems to be
integrated very often into cholesterol-rich membrane domains, termed lipid rafts. Membrane …

Membrane lipid rafts are highly ordered membrane domains enriched in cholesterol,
sphingolipids and gangliosides, which form specialized domains with distinct composition …

Synthetic antitumor lipids are metabolically stable lysophosphatidylcholine derivatives,
encompassing a class of non-mutagenic drugs that selectively target cancerous cells. In this …

The so-called alkylphospholipid analogs (APLs) constitute a family of synthetic antitumor
compounds that target cell membranes. The ether phospholipid edelfosine has been …

The ether lipid edelfosine induces apoptosis selectively in tumor cells and is the prototypic
molecule of a family of synthetic antitumor compounds collectively known as …

Lipid rafts are cholesterol-and sphingolipid-rich liquid ordered microdomains that float within
the liquid disordered bilayer in cell membranes, and can coalesce upon clustering of their …

Research on the nanoscale membrane structures known as lipid rafts is relevant to the fields
of cancer biology, inflammation and ischaemia. Lipid rafts recruit molecules critical to …