Proteolysis in close vicinity of tumor cells is a hallmark of cancer invasion and metastasis.
We show here that mouse mammary tumor virus–polyoma middle T antigen (PyMT) …

Elevated expression of the cysteine protease cathepsin B (CTSB) has been correlated with a
poor prognosis for cancer patients. In order to model high CTSB expression in mammary …

The cysteine protease cathepsin B (CTSB) is frequently overexpressed in human breast
cancer and correlated with a poor prognosis. Genetic deficiency or pharmacological …

Expression levels of the papain-like cysteine protease cathepsin B (Ctsb) have been
positively correlated with mammary tumour progression and metastasis; however, its roles in …

Recent murine studies have demonstrated that tumor‐associated macrophages in the tumor
microenvironment are a key source of the pro‐tumorigenic cysteine protease, cathepsin S …

The lysosomal cysteine proteases cathepsin B (Ctsb) and cathepsin Z (Ctsz, also called
cathepsin X/P) have been implicated in cancer pathogenesis. Compensation of Ctsb by Ctsz …

Background Several studies have found that Cathepsin B (CTSB) is up-regulated in many
tumor types and facilitates tumor progression. However, the role of CTSB in hepatocellular …

Cathepsin B is a lysosomal cysteine proteinase that may participate in cancer progression.
We compared localization of its protein and activity during progression of human colorectal …

Background Inflammatory breast cancer (IBC) is the most aggressive form of breast cancer.
In non-IBC, the cysteine protease cathepsin B (CTSB) is known to be involved in cancer …

Cathepsin-D is an independent marker of poor prognosis in human breast cancer. We
previously showed that human wild-type cathepsin-D, as well as its mutated form devoid of …