Precise pathological classification of non-small cell lung adenocarcinoma and squamous carcinoma based on an integrated platform of targeted metabolome and …

P Cao, S Wu, W Guo, Q Zhang, W Gong, Q Li, R Zhang… - Metabolomics, 2021 - Springer
Background Non-small cell lung cancer (NSCLC) is the leading cause of cancer-related
death worldwide. Lung adenocarcinoma (LUAD) and squamous cell carcinoma (LUSC) are …

Metabolomics and lipidomics in non-small cell lung cancer

W Shi, Y Cheng, H Zhu, L Zhao - Clinica Chimica Acta, 2024 - Elsevier
Due to its insidious nature, lung cancer remains a leading cause of cancer-related deaths
worldwide. Therefore, there is an urgent need to identify sensitive/specific biomarkers for …

Plasma metabolomics reveals risk factors for lung adenocarcinoma

M Yu, W Wen, Y Wang, X Shan, X Yi, W Zhu… - Frontiers in …, 2024 - frontiersin.org
Background Metabolic reprogramming plays a significant role in the advancement of lung
adenocarcinoma (LUAD), yet the precise metabolic changes remain incompletely …

A comprehensive analysis of metabolomics and transcriptomics in non-small cell lung cancer

C Ruiying, L Zeyun, Y Yongliang, Z Zijia, Z Ji, T Xin… - PloS one, 2020 - journals.plos.org
Non-small cell lung cancer (NSCLC) remains a leading cause of cancer death globally.
More accurate and reliable diagnostic methods/biomarkers are urgently needed. Joint …

Integrative metabolomic and lipidomic profiling of lung squamous cell carcinoma for characterization of metabolites and intact lipid species related to the metastatic …

H Lee, H Lee, S Park, M Kim, JY Park, H Jin, K Oh… - Cancers, 2021 - mdpi.com
Simple Summary Non-small cell lung cancer (NSCLC) is the most severe cancer showing a
low 5-year survival rate of metastatic NSCLC, but there are few previous reports for …

Liquid chromatography–mass spectrometry-based tissue metabolic profiling reveals major metabolic pathway alterations and potential biomarkers of lung cancer

L You, Y Fan, X Liu, S Shao, L Guo… - Journal of proteome …, 2020 - ACS Publications
Unclarified molecular mechanism and lack of practical diagnosis biomarkers hinder the
effective treatment of non-small-cell lung cancer. Herein, we performed liquid …

Lipid alterations and subtyping maker discovery of lung cancer based on nontargeted tissue lipidomics using liquid chromatography–mass spectrometry

Y Fan, HAA Noreldeen, L You, X Liu, X Pan… - … of Pharmaceutical and …, 2020 - Elsevier
High morbidity and mortality are still associated with lung cancer, especially non-small cell
lung cancer (NSCLC). Although several studies showed abnormality in lung cancer …

Integrative metabolomics and transcriptomics analysis reveals novel therapeutic vulnerabilities in lung cancer

J Thaiparambil, J Dong, SL Grimm, D Perera… - Cancer …, 2023 - Wiley Online Library
Background Non‐small cell lung cancer (NSCLC) comprises the majority (~ 85%) of all lung
tumors, with lung adenocarcinoma (LUAD) and squamous cell carcinoma (LUSC) being the …

High-resolution metabolomic biomarkers for lung cancer diagnosis and prognosis

S Qi, Q Wu, Z Chen, W Zhang, Y Zhou, K Mao, J Li… - Scientific reports, 2021 - nature.com
Lung cancer is the leading cause of human cancer mortality due to the lack of early
diagnosis technology. The low-dose computed tomography scan (LDCT) is one of the main …

Integration of clinical phenoms and metabolomics facilitates precision medicine for lung cancer

F Yan, C Liu, D Song, Y Zeng, Y Zhan… - Cell Biology and …, 2024 - Springer
Lung cancer is a common malignancy that is frequently associated with systemic metabolic
disorders. Early detection is pivotal to survival improvement. Although blood biomarkers …