The biosynthesis and role of phosphorylcholine in pathogenic and nonpathogenic bacteria

Y Zhang, FEC Jen, KL Fox, JL Edwards… - Trends in …, 2023 - cell.com
Phosphorylcholine (ChoP) can be found in all life forms. Although this molecule was first
thought to be uncommon in bacteria, it is now appreciated that many bacteria express ChoP …

Analysis of Bacterial Phosphorylcholine-Related Genes Reveals an Association between Type-Specific Biosynthesis Pathways and Biomolecules Targeted for …

Y Zhang, FEC Jen, JL Edwards… - Microbiology …, 2023 - Am Soc Microbiol
Many bacterial surface proteins and carbohydrates are modified with phosphorylcholine
(ChoP), which contributes to host mimicry and can also promote colonization and survival in …

Microbial modulation of host immunity with the small molecule phosphorylcholine

SE Clark, JN Weiser - Infection and immunity, 2013 - Am Soc Microbiol
All microorganisms dependent on persistence in a host for survival rely on either hiding from
or modulating host responses to infection. The small molecule phosphorylcholine, or choline …

[HTML][HTML] Review of phosphocholine substituents on bacterial pathogen glycans: synthesis, structures and interactions with host proteins

NM Young, SJ Foote, WW Wakarchuk - Molecular immunology, 2013 - Elsevier
Among the non-carbohydrate components of glycans, the addition of phosphocholine
(ChoP) to the glycans of pathogens occurs more rarely than acetylation or methylation, but it …

Identification of the lic1ABCD operon that controls the phase-variable expression of phosphorylcholine on lipopolysaccharide from Avibacterium paragallinarum

YT Chiang, JH Shien, DH Tan, MK Shieh, CC Liu… - Avian …, 2013 - Taylor & Francis
Phosphorylcholine (ChoP) is an important virulence factor found on the surface of many
mucosal pathogens and its expression enhances bacterial colonization on mucous …

Phosphorylcholine: friend or foe of the immune system?

W Harnett, MM Harnett - Immunology today, 1999 - cell.com
Phosphorylcholine (PC) is a structural component of a variety of prokaryotic and eukaryotic
pathogens. In some cases, PC in infectious agents can benefit the infected host due to its …

Metabolic intermediate acetyl phosphate modulates bacterial virulence via acetylation

J Ren, Y Sang, R Qin, Y Su, Z Cui, Z Mang… - Emerging microbes & …, 2019 - Taylor & Francis
Accumulating evidence indicates that bacterial metabolism plays an important role in
virulence. Acetyl phosphate (AcP), the high-energy intermediate of the …

Molecular characterization of phosphorylcholine expression on the lipooligosaccharide of Histophilus somni

SF Elswaifi, FS Michael, A Sreenivas, A Cox… - Microbial …, 2009 - Elsevier
Histophilus somni (Haemophilus somnus) is an important pathogen of cattle that is
responsible for respiratory disease, septicemia, and systemic diseases such as thrombotic …

[HTML][HTML] Phosphorylcholine Allows for Evasion of Bactericidal Antibody by Haemophilus influenzae

SE Clark, J Snow, J Li, TA Zola, JN Weiser - PLoS pathogens, 2012 - journals.plos.org
The human pathogen Haemophilus influenzae has the ability to quickly adapt to different
host environments through phase variation of multiple structures on its lipooligosaccharide …

Novel Phosphorylcholine-Containing Protein of Pseudomonas aeruginosa Chronic Infection Isolates Interacts with Airway Epithelial Cells

M Barbier, A Oliver, J Rao, SL Hanna… - The Journal of …, 2008 - academic.oup.com
Pseudomonas aeruginosa undergoes phase variation in the expression of the
phosphorylcholine (ChoP) epitope, a structure crucial for the virulence of several respiratory …