The biosynthesis and role of phosphorylcholine in pathogenic and nonpathogenic bacteria
Y Zhang, FEC Jen, KL Fox, JL Edwards… - Trends in …, 2023 - cell.com
Phosphorylcholine (ChoP) can be found in all life forms. Although this molecule was first
thought to be uncommon in bacteria, it is now appreciated that many bacteria express ChoP …
thought to be uncommon in bacteria, it is now appreciated that many bacteria express ChoP …
Analysis of Bacterial Phosphorylcholine-Related Genes Reveals an Association between Type-Specific Biosynthesis Pathways and Biomolecules Targeted for …
Y Zhang, FEC Jen, JL Edwards… - Microbiology …, 2023 - Am Soc Microbiol
Many bacterial surface proteins and carbohydrates are modified with phosphorylcholine
(ChoP), which contributes to host mimicry and can also promote colonization and survival in …
(ChoP), which contributes to host mimicry and can also promote colonization and survival in …
Microbial modulation of host immunity with the small molecule phosphorylcholine
SE Clark, JN Weiser - Infection and immunity, 2013 - Am Soc Microbiol
All microorganisms dependent on persistence in a host for survival rely on either hiding from
or modulating host responses to infection. The small molecule phosphorylcholine, or choline …
or modulating host responses to infection. The small molecule phosphorylcholine, or choline …
[HTML][HTML] Review of phosphocholine substituents on bacterial pathogen glycans: synthesis, structures and interactions with host proteins
NM Young, SJ Foote, WW Wakarchuk - Molecular immunology, 2013 - Elsevier
Among the non-carbohydrate components of glycans, the addition of phosphocholine
(ChoP) to the glycans of pathogens occurs more rarely than acetylation or methylation, but it …
(ChoP) to the glycans of pathogens occurs more rarely than acetylation or methylation, but it …
Identification of the lic1ABCD operon that controls the phase-variable expression of phosphorylcholine on lipopolysaccharide from Avibacterium paragallinarum
YT Chiang, JH Shien, DH Tan, MK Shieh, CC Liu… - Avian …, 2013 - Taylor & Francis
Phosphorylcholine (ChoP) is an important virulence factor found on the surface of many
mucosal pathogens and its expression enhances bacterial colonization on mucous …
mucosal pathogens and its expression enhances bacterial colonization on mucous …
Phosphorylcholine: friend or foe of the immune system?
W Harnett, MM Harnett - Immunology today, 1999 - cell.com
Phosphorylcholine (PC) is a structural component of a variety of prokaryotic and eukaryotic
pathogens. In some cases, PC in infectious agents can benefit the infected host due to its …
pathogens. In some cases, PC in infectious agents can benefit the infected host due to its …
Metabolic intermediate acetyl phosphate modulates bacterial virulence via acetylation
J Ren, Y Sang, R Qin, Y Su, Z Cui, Z Mang… - Emerging microbes & …, 2019 - Taylor & Francis
Accumulating evidence indicates that bacterial metabolism plays an important role in
virulence. Acetyl phosphate (AcP), the high-energy intermediate of the …
virulence. Acetyl phosphate (AcP), the high-energy intermediate of the …
Molecular characterization of phosphorylcholine expression on the lipooligosaccharide of Histophilus somni
SF Elswaifi, FS Michael, A Sreenivas, A Cox… - Microbial …, 2009 - Elsevier
Histophilus somni (Haemophilus somnus) is an important pathogen of cattle that is
responsible for respiratory disease, septicemia, and systemic diseases such as thrombotic …
responsible for respiratory disease, septicemia, and systemic diseases such as thrombotic …
[HTML][HTML] Phosphorylcholine Allows for Evasion of Bactericidal Antibody by Haemophilus influenzae
The human pathogen Haemophilus influenzae has the ability to quickly adapt to different
host environments through phase variation of multiple structures on its lipooligosaccharide …
host environments through phase variation of multiple structures on its lipooligosaccharide …
Novel Phosphorylcholine-Containing Protein of Pseudomonas aeruginosa Chronic Infection Isolates Interacts with Airway Epithelial Cells
Pseudomonas aeruginosa undergoes phase variation in the expression of the
phosphorylcholine (ChoP) epitope, a structure crucial for the virulence of several respiratory …
phosphorylcholine (ChoP) epitope, a structure crucial for the virulence of several respiratory …