In vitro and in vivo models for studying SARS-CoV-2, the etiological agent responsible for COVID-19 pandemic

RB Rosa, WM Dantas, JCF do Nascimento… - Viruses, 2021 - mdpi.com
The emergence and rapid worldwide spread of severe acute respiratory syndrome
coronavirus 2 (SARS-CoV-2) has prompted the scientific community to rapidly develop in …

[PDF][PDF] A mouse model of SARS-CoV-2 infection and pathogenesis

SH Sun, Q Chen, HJ Gu, G Yang, YX Wang… - Cell host & …, 2020 - cell.com
Since December 2019, a novel coronavirus SARS-CoV-2 has emerged and rapidly spread
throughout the world, resulting in a global public health emergency. The lack of vaccine and …

[HTML][HTML] Animal models for COVID-19: hamsters, mouse, ferret, mink, tree shrew, and non-human primates

S Shou, M Liu, Y Yang, N Kang, Y Song… - Frontiers in …, 2021 - frontiersin.org
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is a novel coronavirus
causing acute respiratory tract infection in humans. The virus has the characteristics of rapid …

Animal models for SARS‐CoV‐2 research: a comprehensive literature review

K Pandey, A Acharya, M Mohan, CL Ng… - Transboundary and …, 2021 - Wiley Online Library
Emerging and re‐emerging viral diseases can create devastating effects on human lives
and may also lead to economic crises. The ongoing COVID‐19 pandemic due to the novel …

[HTML][HTML] Experimental models of COVID-19

LA Caldera-Crespo, MJ Paidas, S Roy… - Frontiers in cellular …, 2022 - frontiersin.org
COVID-19 is the most consequential pandemic of the 21st century. Since the earliest stage
of the 2019-2020 epidemic, animal models have been useful in understanding the …

In vitro lung models and their application to study SARS-CoV-2 pathogenesis and disease

N Heinen, M Klöhn, E Steinmann, S Pfaender - Viruses, 2021 - mdpi.com
SARS-CoV-2 has spread across the globe with an astonishing velocity and lethality that has
put scientist and pharmaceutical companies worldwide on the spot to develop novel …

Mouse-adapted SARS-CoV-2 replicates efficiently in the upper and lower respiratory tract of BALB/c and C57BL/6J mice

J Wang, L Shuai, C Wang, R Liu, X He, X Zhang… - Protein & …, 2020 - academic.oup.com
As of June, 2020, more than ten million cases of COVID-19 have been reported worldwide.
The causative pathogen of the disease is a novel coronavirus named severe acute …

In vitro and animal models for SARS-CoV-2 research

K Takayama - Trends in pharmacological sciences, 2020 - cell.com
Basic research on SARS-CoV-2 is essential to understand its detailed pathophysiology and
identify best drug targets. Models that can faithfully reproduce the viral life cycle and …

[HTML][HTML] Choosing a cellular model to study SARS-CoV-2

GA Pires De Souza, M Le Bideau, C Boschi… - Frontiers in Cellular …, 2022 - frontiersin.org
As new pathogens emerge, new challenges must be faced. This is no different in infectious
disease research, where identifying the best tools available in laboratories to conduct an …

Animal models for emerging coronavirus: progress and new insights

L Yuan, Q Tang, T Cheng, N Xia - Emerging microbes & infections, 2020 - Taylor & Francis
The emergences of coronaviruses have caused a serious global public health problem
because their infection in humans caused the severe acute respiratory disease and deaths …