DNA inverted repeats (IRs) are hotspots of genomic instability in both prokaryotes and
eukaryotes. This feature is commonly attributed to their ability to fold into hairpin-or cruciform …

During S-phase, the genome is extremely vulnerable and the progression of replication forks
is often threatened by exogenous and endogenous challenges. When replication fork …

Defects in chromosome replication can lead to translocations that are thought to result from
recombination events at stalled DNA replication forks. The progression of forks is controlled …

Accurate and complete replication of the genome in every cell division is a prerequisite of
genomic stability. Thus, both prokaryotic and eukaryotic replication forks are extremely …

DNA sequences that form secondary structures or bind protein complexes are known
barriers to replication and potential inducers of genome instability. In order to determine …

The progress of replication forks is often threatened in vivo, both by DNA damage and by
proteins bound to the template. Blocked forks must somehow be restarted, and the original …

Gene-specific repeat instability is responsible for> 36 human diseases. Active instability
varies in a tissue-, developmental stage-and locus-specific manner and occurs in both …

Faithful genome duplication and inheritance require the complete resolution of all
intertwines within the parental DNA duplex. This is achieved by topoisomerase action ahead …

The advance of a DNA replication fork requires an unwinding of the parental double helix.
This in turn creates a positive superhelical stress, a (+)-ΔLk, that must be relaxed by …

The unwinding of the parental DNA duplex during replication causes a positive linking
number difference, or superhelical strain, to build up around the elongating replication fork …