Nitric oxide synthase inhibition and cerebrovascular regulation

C Iadecola, DA Pelligrino… - Journal of Cerebral …, 1994 - journals.sagepub.com
There is increasing evidence that nitric oxide (NO) is an important molecular messenger
involved in a wide variety of biological processes. Recent data suggest that NO is also …

Cerebral blood flow regulation by nitric oxide: recent advances

N Toda, K Ayajiki, T Okamura - Pharmacological reviews, 2009 - ASPET
Nitric oxide (NO) is undoubtedly quite an important intercellular messenger in cerebral and
peripheral hemodynamics. This molecule, formed by constitutive isomers of NO synthase …

Nitric oxide and focal cerebral ischemia: multiplicity of actions and diverse outcome.

DA Dawson - Cerebrovascular and brain metabolism reviews, 1994 - europepmc.org
The original observation that inhibitors of nitric oxide (NO) synthesis can antagonize
glutamate toxicity in cell culture has led to extensive investigation of the role of NO in the …

Cerebral blood flow regulation by nitric oxide in neurological disorders

N Toda, K Ayajiki, T Okamura - Canadian journal of physiology …, 2009 - cdnsciencepub.com
There has been a rapid increase in the amount of information on the physiological and
pathophysiological roles of nitric oxide (NO) in the brain. This molecule, which is formed by …

Nitric oxide and the cerebral circulation.

FM Faraci, JE Brian Jr - Stroke, 1994 - Am Heart Assoc
Nitric oxide (NO) is a potent vasodilator that was initially described as the mediator of
endothelium-dependent relaxation (endothelium-derived relaxing factor, EDRF). It is now …

The complex role of nitric oxide in the pathophysiology of focal cerebral ischemia

T Dalkara, MA Moskowitz - Brain pathology, 1994 - Wiley Online Library
Nitrogen monoxide (NO) has recently emerged as an important mediator of cellular and
molecular events which impacts the pathophysiology of cerebral ischemia. Although …

Time dependence of effect of nitric oxide synthase inhibition on cerebral ischemic damage

F Zhang, S Xu, C Iadecola - Journal of Cerebral Blood Flow …, 1995 - journals.sagepub.com
Nitric oxide, a potent vasodilator and an inhibitor of platelet aggregation, may be beneficial
in the early stages of focal cerebral ischemia as it may facilitate collateral blood flow to the …

Nitric oxide in the nervous system

J Zhang, SH Snyder - Annual Review of Pharmacology and …, 1995 - annualreviews.org
Nitric oxide (NO) has only recently been appreciated as a normal biologic substance with a
role in signal transduction. It was first identified as endothe lial-derived relaxing factor in …

Nitric oxide: considerations for the treatment of ischemic stroke

NA Terpolilli, MA Moskowitz… - Journal of cerebral …, 2012 - journals.sagepub.com
Some 40 years ago it was recognized by Furchgott and colleagues that the endothelium
releases a vasodilator, endothelium-derived relaxing factor (EDRF). Later on, several …

Physiological and pathophysiological roles of nitric oxide in the central nervous system

C Szabó - Brain research bulletin, 1996 - Elsevier
Nitric oxide (NO) is produced by three distinct isoforms of nitric oxide synthases in the central
nervous system. Here, the roles of nitric oxide in the central nervous system are reviewed …