Lipopolysaccharide (LPS) is the main structural component of the outer membrane of most
Gram-negative bacteria and has diverse immunostimulatory and procoagulant effects. Even …

Sepsis is defined as organ dysfunction due to a dysregulated systemic host response to
infection. During gram-negative bacterial infection and other acute illness such as …

Endotoxin, more accurately referred to as lipopolysaccharide (LPS), is recognized as the
most potent microbial mediator implicated in the pathogenesis of sepsis and septic shock …

Lipopolysaccharide (LPS), a main constituent of Gram-negative bacterial membrane,
specifically activates Toll-like receptor 4, leading to the production of pleiotropic …

The complex pathophysiology of sepsis makes it a syndrome with limited therapeutic options
and a high mortality rate. Gram-negative bacteria containing lipopolysaccharides (LPS) in …

Lipopolysaccharide is a component of the gram-negative bacterial cell wall that is
responsible for 25,000-50,000 deaths in the United States each year. The sequelae of gram …

Inflammation is a key feature in the pathogenesis of sepsis and acute respiratory distress
syndrome (ARDS). Sepsis and ARDS continue to be associated with high mortality. A key …

Cross-talk between enteral microbiota and human host is essential for the development and
maintenance of the human gastrointestinal and systemic immune systems. The presence of …

Lipopolysaccharide (LPS) from Gram-negative bacteria is one of the most potent innate
immune-activating stimuli known. Here we review the current understanding of LPS effects …

Systemic inflammation is associated with chronic disease and is purported to be a main
pathogenic mechanism underlying metabolic conditions. Microbes harbored in the host …