Osteoarthritis (OA) is a chronic degenerative joint disorder characterized by destruction of
the articular cartilage, subchondral bone alterations and synovitis. Current treatments are …

Osteoarthritis (OA), the most common form of degenerative joint disease, is linked to high
morbidity. It is predicted to be the single greatest cause of disability in the general population …

[Frontiers in Bioscience 4, d762-771, October 15, 1999] 762 FUTURE DIRECTIONS FOR
RESEARCH AND TREATMENT OF OSTEOARTHRITIS Charl Page 1 [Frontiers in Bioscience 4 …

Osteoarthritis (OA) is the most prevalent joint disease in older people and is characterized
by the progressive destruction of articular cartilage, synovial inflammation, changes in …

Although osteoarthritis (OA) is the most common musculoskeletal condition that causes
significant health and social problems worldwide, its exact etiology is still unclear. With an …

Recent developments in genetics/genomics of osteoarthritis (OA) are discussed to improve
our understanding of OA pathophysiology. The discovery of a novel variant near the NCOA3 …

Highlights•Different OA etiologies present a challenge for developing a single targeted
therapy.•Common mechanisms occur in inflammatory, mechanical, and oxidative stress in …

Osteoarthritis (OA) is a chronic, progressive degenerative whole joint disease that affects the
articular cartilage, subchondral bone, ligaments, capsule, and synovium. While it is still …

This review focuses on the new perspectives which can provide insight into the crucial
pathways that drive cartilage-bone physiopathology. In particular, we discuss the critical …

Osteoarthritis (OA) is the most common joint disorder and a leading cause of disability.
Current treatments for OA can improve symptoms but do not delay the progression of …